New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Animals
Carbon Tetrachloride
/ pharmacology
Diet, High-Fat
Disease Models, Animal
Disease Progression
Fatty Liver
/ metabolism
Inflammation
Liver
/ metabolism
Liver Cirrhosis
/ metabolism
Male
Metabolic Syndrome
/ metabolism
Non-alcoholic Fatty Liver Disease
/ etiology
Phenobarbital
/ pharmacology
Rats
Rats, Wistar
Transcriptome
/ genetics
cirrhosis
hepatic fibrosis
portal hypertension
steatohepatitis
steatosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
received:
22
07
2019
revised:
06
09
2019
accepted:
06
09
2019
entrez:
13
9
2019
pubmed:
13
9
2019
medline:
12
6
2020
Statut:
epublish
Résumé
Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease. However, most available animal models fail to reflect the whole spectrum of the disease. Liver fibrosis and portal hypertension are the strongest prognostic markers in advanced NASH. We herein aimed at developing a new model of NASH in male rats, obtained using a multi-hit protocol that combines the administration of a high fat and high-cholesterol diet with CCl
Identifiants
pubmed: 31510105
pii: cells8091062
doi: 10.3390/cells8091062
pmc: PMC6770035
pii:
doi:
Substances chimiques
Carbon Tetrachloride
CL2T97X0V0
Phenobarbital
YQE403BP4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Gastroenterology. 2007 Sep;133(3):959-66
pubmed: 17854599
Hepatology. 2015 May;61(5):1547-54
pubmed: 25125077
Lab Invest. 2015 Oct;95(10):1130-44
pubmed: 26214582
J Hepatol. 2017 Dec;67(6):1265-1273
pubmed: 28803953
Gut. 2015 Sep;64(9):1434-43
pubmed: 25500203
Hepatol Commun. 2019 Apr 22;3(7):987-1000
pubmed: 31304452
Clin Exp Pharmacol Physiol. 2013 Jul;40(7):422-30
pubmed: 23611112
Hepatology. 2019 Apr 16;:null
pubmed: 30993748
Gastroenterology. 2018 Nov;155(5):1564-1577
pubmed: 30055171
J Hepatol. 2018 Aug;69(2):385-395
pubmed: 29572095
Gastroenterology. 2018 Oct;155(4):1140-1153
pubmed: 29990488
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G449-68
pubmed: 23275613
Hepatology. 2011 Mar;53(3):810-20
pubmed: 21319198
Nature. 2006 Dec 14;444(7121):881-7
pubmed: 17167477
Dig Dis Sci. 2016 May;61(5):1325-36
pubmed: 26626909
Autophagy. 2012 May 1;8(5):849-50
pubmed: 22617442
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nutr Metab (Lond). 2007 Feb 21;4:4
pubmed: 17313679
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411
pubmed: 28487545
Dis Model Mech. 2009 May-Jun;2(5-6):206-10
pubmed: 19407324
Genome Res. 2004 May;14(5):942-50
pubmed: 15123590
Am J Epidemiol. 2013 Jul 1;178(1):38-45
pubmed: 23703888
Aging Dis. 2019 Aug 01;10(4):684-698
pubmed: 31440376
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):1019-1030
pubmed: 30055295
Nutrients. 2017 Dec 29;10(1):null
pubmed: 29286303
Clin Liver Dis (Hoboken). 2018 Apr 20;11(4):87-91
pubmed: 30992796
Clin Gastroenterol Hepatol. 2012 Sep;10(9):1028-33.e2
pubmed: 22610002
PLoS One. 2014 Dec 23;9(12):e115922
pubmed: 25535951
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
BMC Gastroenterol. 2017 Mar 7;17(1):35
pubmed: 28264657
Annu Rev Pathol. 2016 May 23;11:451-96
pubmed: 26980160
Annu Rev Nutr. 1994;14:269-96
pubmed: 7946521
Philos Trans R Soc Lond B Biol Sci. 1985 Dec 17;311(1152):633-45
pubmed: 2869522
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Liver Transpl. 2013 Jun;19(6):627-33
pubmed: 23495130
J Clin Biochem Nutr. 2009 May;44(3):239-46
pubmed: 19430612
PLoS One. 2012;7(4):e32785
pubmed: 22509248
Obes Surg. 2008 Apr;18(4):378-85
pubmed: 18264740
J Hepatol. 2017 Jan;66(1):86-94
pubmed: 27545498
Aging Cell. 2018 Dec;17(6):e12829
pubmed: 30260562
Hepatol Res. 2010 Jun;40(6):594-604
pubmed: 20618457