Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study.
Animals
Behavior, Animal
Biomarkers
Cell Survival
Corpus Striatum
/ metabolism
Disease Models, Animal
Excitatory Postsynaptic Potentials
Glutamic Acid
/ metabolism
Image Processing, Computer-Assisted
Immunohistochemistry
Male
Neurodegenerative Diseases
/ diagnostic imaging
Positron-Emission Tomography
Rats
Receptor, Metabotropic Glutamate 5
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 09 2019
09 09 2019
Historique:
received:
21
03
2019
accepted:
23
08
2019
entrez:
11
9
2019
pubmed:
11
9
2019
medline:
28
10
2020
Statut:
epublish
Résumé
Metabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator of glutamate-induced excitotoxicity. To study the behavior of mGluR5 following localized excitotoxicity, we utilised a pharmacological model that portrays exacerbated neuronal glutamate release, mediated by the endogenous excitotoxin quinolinic acid (QA). Using longitudinal positron emission tomography (PET) with [
Identifiants
pubmed: 31501497
doi: 10.1038/s41598-019-49356-x
pii: 10.1038/s41598-019-49356-x
pmc: PMC6733799
doi:
Substances chimiques
Biomarkers
0
Grm5 protein, rat
0
Receptor, Metabotropic Glutamate 5
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12916Références
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