Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?
Acute Disease
Antiviral Agents
/ therapeutic use
Chemokine CXCL10
/ blood
Hepatitis C
/ immunology
Hepatitis C, Chronic
/ diagnosis
Humans
Immunomodulation
Interferon-alpha
/ therapeutic use
Interferon-gamma
/ therapeutic use
Interferons
/ genetics
Liver
/ pathology
Polymorphism, Single Nucleotide
Prognosis
Receptors, CXCR3
/ immunology
Ribavirin
/ therapeutic use
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
02
2019
revised:
19
04
2019
accepted:
30
04
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
25
1
2020
Statut:
epublish
Résumé
Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and "chronic hepatitis C virus (HCV) infection" (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B can identify patients with acute HCV infection most likely to undergo spontaneous HCV clearance and those in need of early antiviral therapy. In CHC, the HCV and intrahepatic interferon- (IFN-)
Identifiants
pubmed: 31485460
doi: 10.1155/2019/5878960
pmc: PMC6702819
doi:
Substances chimiques
Antiviral Agents
0
CXCR3 protein, human
0
Chemokine CXCL10
0
interferon-lambda, human
0
Interferon-alpha
0
Receptors, CXCR3
0
Ribavirin
49717AWG6K
Interferon-gamma
82115-62-6
Interferons
9008-11-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5878960Déclaration de conflit d'intérêts
The authors have nothing to declare.
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