Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.
Animals
Antimicrobial Cationic Peptides
/ administration & dosage
Bulimia
/ physiopathology
Diet, High-Fat
Ghrelin
/ administration & dosage
Glycine
/ analogs & derivatives
Infusions, Intraventricular
Male
Mice
Oligopeptides
/ pharmacology
Receptors, Ghrelin
/ agonists
Time Factors
Triazoles
/ pharmacology
constitutive GHSR activity
food reward
palatable food
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
05
06
2019
revised:
16
08
2019
accepted:
27
08
2019
pubmed:
31
8
2019
medline:
15
12
2020
entrez:
31
8
2019
Statut:
ppublish
Résumé
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor that is highly expressed in the central nervous system. GHSR acts as a receptor for ghrelin and for liver-expressed antimicrobial peptide 2 (LEAP2), which blocks ghrelin-evoked activity. GHSR also displays ligand-independent activity, including a high constitutive activity that signals in the absence of ghrelin and is reduced by LEAP2. GHSR activity modulates a variety of food intake-related behaviours, including binge eating. Previously, we reported that GHSR-deficient mice daily and time-limited exposed to a high-fat (HF) diet display an attenuated binge-like HF intake compared to wild-type mice. In the present study, we aimed to determine whether ligand-independent GHSR activity affects binge-like HF intake in a 4-day binge-like eating protocol. We found that plasma levels of ghrelin and LEAP2 were not modified in mice exposed to this binge-like eating protocol. Moreover, systemic administration of ghrelin or LEAP2 did not alter HF intake in our experimental conditions. Interestingly, we found that central administration of LEAP2 or K-(D-1-Nal)-FwLL-NH
Substances chimiques
Antimicrobial Cationic Peptides
0
GHRP-6, Lys(3)-
0
Ghrelin
0
Leap2 protein, mouse
0
N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide
0
Oligopeptides
0
Receptors, Ghrelin
0
Triazoles
0
Glycine
TE7660XO1C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12785Informations de copyright
© 2019 British Society for Neuroendocrinology.
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