The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.
Amino Acid Motifs
/ genetics
Animals
Cell Differentiation
/ genetics
Encephalomyelitis, Autoimmune, Experimental
/ drug therapy
Gene Expression Regulation
/ drug effects
Genetic Loci
HEK293 Cells
Humans
Interleukin-17
/ genetics
Mice
Mice, Transgenic
Multiple Sclerosis
/ drug therapy
Nuclear Receptor Subfamily 1, Group D, Member 1
/ agonists
Nuclear Receptor Subfamily 1, Group F, Member 3
/ immunology
Pyrrolidines
/ pharmacology
RNA-Seq
Response Elements
/ genetics
Th17 Cells
/ immunology
Thiophenes
/ pharmacology
autoimmunity
nuclear receptors
transcriptional repressor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
pubmed:
29
8
2019
medline:
9
4
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encoded by
Identifiants
pubmed: 31455731
pii: 1907563116
doi: 10.1073/pnas.1907563116
pmc: PMC6744854
doi:
Substances chimiques
Il17a protein, mouse
0
Il17f protein, mouse
0
Interleukin-17
0
Nr1d1 protein, mouse
0
Nuclear Receptor Subfamily 1, Group D, Member 1
0
Nuclear Receptor Subfamily 1, Group F, Member 3
0
Pyrrolidines
0
Rorc protein, mouse
0
SR9009
0
Thiophenes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18528-18536Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL105278
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007198
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIH HHS
ID : S10 OD023689
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107027
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116885
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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