Oral mobility reflects rate of progression in advanced Friedreich's ataxia.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
17
06
2019
revised:
18
07
2019
accepted:
06
08
2019
pubmed:
27
8
2019
medline:
19
5
2020
entrez:
27
8
2019
Statut:
ppublish
Résumé
Our objective was to identify a sensitive marker of disease progression in Friedreich's ataxia. We prospectively evaluated speech, voice, and oromotor function in 40 patients at two timepoints. The mean disease duration was 20.8 ± 9.8 years and mean SARA score 23.7 ± 8.6 at baseline. Oral motor mobility, assessed by a combination of movements of the face, eyes, cheeks, lips, and tongue, decreased significantly after 1 year (P < 0.0001). The standardized response mean over 12 months was considered as large for oral mobility (1.26) but small for SARA (0.12). Oral mobility could therefore be a sensitive marker in therapeutic trials.
Identifiants
pubmed: 31448573
doi: 10.1002/acn3.50879
pmc: PMC6764486
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1888-1892Subventions
Organisme : AFAF French Friedreich Ataxia Association
Pays : International
Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Références
Mov Disord. 2012 Jan;27(1):135-8
pubmed: 22076850
Neurology. 2006 Jun 13;66(11):1717-20
pubmed: 16769946
Rev Laryngol Otol Rhinol (Bord). 2004;125(5):307-12
pubmed: 15856833
J Neurol. 2012 Mar;259(3):420-6
pubmed: 21805332
Clin Neurophysiol. 2018 Jun;129(6):1121-1129
pubmed: 29625343
Int J Lang Commun Disord. 2012 Jan-Feb;47(1):65-76
pubmed: 22268902
Dysphagia. 2017 Oct;32(5):626-635
pubmed: 28474131
Mov Disord. 2010 Mar 15;25(4):426-32
pubmed: 20063431
Mov Disord. 2010 Jan 15;25(1):108-11
pubmed: 20014117
Brain Lang. 1980 May;10(1):39-50
pubmed: 7378727
J Clin Epidemiol. 2000 May;53(5):459-68
pubmed: 10812317
Folia Phoniatr Logop. 2010;62(3):97-103
pubmed: 20424464
Brain. 2008 May;131(Pt 5):1352-61
pubmed: 18378516
Int Arch Otorhinolaryngol. 2017 Jan;21(1):79-85
pubmed: 28050212
J Neurol. 2012 Nov;259(11):2471-7
pubmed: 22669353
Lancet Neurol. 2016 Dec;15(13):1346-1354
pubmed: 27839651
N Engl J Med. 1996 Oct 17;335(16):1169-75
pubmed: 8815938
J Neurol. 2014 Feb;261(2):392-9
pubmed: 24371004
Brain. 2008 Aug;131(Pt 8):2002-12
pubmed: 18515321
Brain. 1981 Sep;104(3):589-620
pubmed: 7272714