TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity.
1-Methylhistidine
3-Methylhistidine
Amino acids
Cod
Creatine
Salmon
TMAO
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
14
05
2019
accepted:
02
08
2019
pubmed:
12
8
2019
medline:
24
6
2021
entrez:
12
8
2019
Statut:
ppublish
Résumé
To identify biomarkers to assess participants' compliance in an intervention study with high intake of cod or salmon, compared to a fish-free diet. In this randomised clinical trial, 62 healthy overweight/obese participants consumed 750 g/week of either cod (N = 21) or salmon (N = 22) across 5 weekly dinners, or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. After cod intake, serum concentrations of trimethylamine N-oxide (TMAO, p = 0.0043), creatine (p = 0.024) and 1-methylhistidine (1-MeHis, p = 0.014), and urine concentrations (relative to creatinine) of TMAO (p = 2.8 × 10 TMAO measured in serum or urine is a potential biomarker of cod intake, and 1-MeHis measured in serum or urine is a potential biomarker of salmon intake.
Identifiants
pubmed: 31401679
doi: 10.1007/s00394-019-02076-4
pii: 10.1007/s00394-019-02076-4
doi:
Substances chimiques
Biomarkers
0
Methylamines
0
Methylhistidines
0
1-methylhistidine
332-80-9
trimethyloxamine
FLD0K1SJ1A
Creatine
MU72812GK0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2249-2259Références
Zheng J, Huang T, Yu Y, Hu X, Yang B, Li D (2012) Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies. Public Health Nutr 15:725–737
pubmed: 21914258
Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB (2008) Fish consumption and risk of major chronic disease in men. Am J Clin Nutr 88:1618–1625
pubmed: 19064523
pmcid: 2613199
Nkondjock A, Receveur O (2003) Fish-seafood consumption, obesity, and risk of type 2 diabetes: an ecological study. Diabetes Metab 29:635–642. https://www.em-consulte.com/article/80269/alertePM
Alhassan A, Young J, Lean MEJ, Lara J (2017) Consumption of fish and vascular risk factors: a systematic review and meta-analysis of intervention studies. Atherosclerosis 266:87–94
pubmed: 28992469
Feskens EJ, Bowles CH, Kromhout D (1991) Inverse association between fish intake and risk of glucose intolerance in normoglycemic elderly men and women. Diabetes Care 14:935–941
pubmed: 1797505
Whelton SP, He J, Whelton PK, Muntner P (2004) Meta-analysis of observational studies on fish intake and coronary heart disease. Am J Cardiol 93:1119–1123
pubmed: 15110203
Kromhout D, Bosschieter EB, de Lezenne Coulander C (1985) The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 312:1205–1209
pubmed: 3990713
Djousse L, Akinkuolie AO, Wu JH, Ding EL, Gaziano JM (2012) Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis. Clin Nutr 31:846–853
pubmed: 22682084
pmcid: 3509256
He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, Goldbourt U, Greenland P (2004) Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke 35:1538–1542
pubmed: 15155968
He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, Greenland P (2004) Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 109:2705–2711
pubmed: 15184295
Patel PS, Forouhi NG, Kuijsten A, Schulze MB, van Woudenbergh GJ, Ardanaz E, Amiano P, Arriola L, Balkau B, Barricarte A, Beulens JW, Boeing H, Buijsse B, Crowe FL, de Lauzon-Guillan B, Fagherazzi G, Franks PW, Gonzalez C, Grioni S, Halkjaer J, Huerta JM, Key TJ, Kuhn T, Masala G, Nilsson P, Overvad K, Panico S, Quiros JR, Rolandsson O, Sacerdote C, Sanchez MJ, Schmidt EB, Slimani N, Spijkerman AM, Teucher B, Tjonneland A, Tormo MJ, Tumino R, der van AD, van der Schow YT, Sharp SJ, Langenberg C, Feskens EJ, Riboli E, Wareham NJ (2012) The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study. Am J Clin Nutr 95:1445–1453
pubmed: 22572642
pmcid: 3623039
van Woudenbergh GJ, van Ballegooijen AJ, Kuijsten A, Sijbrands EJ, van Rooij FJ, Geleijnse JM, Hofman A, Witteman JC, Feskens EJ (2009) Eating fish and risk of type 2 diabetes: a population-based, prospective follow-up study. Diabetes Care 32:2021–2026
pubmed: 19675200
pmcid: 2768220
Schulze MB, Manson JE, Willett WC, Hu FB (2003) Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women. Diabetologia 46:1465–1473
pubmed: 14576980
Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313:84–90
pubmed: 8688759
pmcid: 2351515
Kaushik M, Mozaffarian D, Spiegelman D, Manson JE, Willett WC, Hu FB (2009) Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus. Am J Clin Nutr 90:613–620
pubmed: 19625683
pmcid: 2728645
Djousse L, Gaziano JM, Buring JE, Lee IM (2011) Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr 93:143–150
pubmed: 20980491
Drotningsvik A, Midttun O, McCann A, Ueland PM, Hogoy I, Gudbrandsen OA (2018) Dietary intake of cod protein beneficially affects concentrations of urinary markers of kidney function and results in lower urinary loss of amino acids in obese Zucker fa/fa rats. Br J Nutr 120:740–750
pubmed: 30156176
Drotningsvik A, Midttun O, Vikoren LA, McCann A, Ueland PM, Mellgren G, Gudbrandsen OA (2019) Urine and plasma concentrations of amino acids and plasma vitamin status differs, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. Br J Nutr. https://doi.org/10.1017/S0007114519001284
doi: 10.1017/S0007114519001284
pubmed: 31397239
Yazdekhasti N, Brandsch C, Schmidt N, Schloesser A, Huebbe P, Rimbach G, Stangl GI (2016) Fish protein increases circulating levels of trimethylamine-N-oxide and accelerates aortic lesion formation in apoE null mice. Mol Nutr Food Res 60:358–368
pubmed: 26502377
Schmedes M, Balderas C, Aadland EK, Jacques H, Lavigne C, Graff IE, Eng O, Holthe A, Mellgren G, Young JF, Sundekilde UK, Liaset B, Bertram HC (2018) The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: results from a randomized crossover intervention study in healthy adults. Nutrients 10:598–614
pmcid: 5986478
Helland A, Bratlie M, Hagen IV, Mjos SA, Sornes S, Ingvar Halstensen A, Brokstad KA, Sveier H, Rosenlund G, Mellgren G, Gudbrandsen OA (2017) High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial. Br J Nutr 117:1368–1378
pubmed: 28606215
Midttun O, Kvalheim G, Ueland PM (2013) High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS. Anal Bioanal Chem 405:2009–2017
pubmed: 23232958
Midttun O, McCann A, Aarseth O, Krokeide M, Kvalheim G, Meyer K, Ueland PM (2016) Combined measurement of 6 fat-soluble vitamins and 26 water-soluble functional vitamin markers and amino acids in 50 muL of serum or plasma by high-throughput mass spectrometry. Anal Chem 88:10427–10436
pubmed: 27715010
Midttun O, Hustad S, Ueland PM (2009) Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 23:1371–1379
pubmed: 19337982
Christman AA (1971) Determination of anserine, carnosine, and other histidine compounds in muscle extractives. Anal Biochem 39:181–187
pubmed: 5544591
Bidlingmeyer BA, Cohen SA, Tarvin TL, Frost B (1987) A new, rapid, high-sensitivity analysis of amino acids in food type samples. J Assoc Off Anal Chem 70:241–247
pubmed: 3571118
Nitrogen. Determination in foods and feeds according to Kjeldahl. NMKL 2003; Method No. 6, 4. Ed
Streiner DL (2015) Best (but oft-forgotten) practices: the multiple problems of multiplicity-whether and how to correct for many statistical tests. Am J Clin Nutr 102:721–728
pubmed: 26245806
van Waarde A (1988) Biochemistry of non-protein nitrogenous compounds in fish including the use of amino acids for anaerobic energy production. Comp Biochem Physiol B Comp Biochem 91B:207–228
Davey CL (1960) The significance of carnosine and anserine in striated skeletal muscle. Arch Biochem Biophys 89:303–308
pubmed: 13814256
Crush KG (1970) Carnosine and related substances in animal tissues. Comp Biochem Physiol 34:3–30
pubmed: 4988625
Sjolin J, Hjort G, Friman G, Hambraeus L (1987) Urinary excretion of 1-methylhistidine: a qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources. Metabolism 36:1175–1184
pubmed: 3683186
Clark JF (1998) Creatine: a review of its nutritional applications in sport. Nutrition 14:322–324
pubmed: 9583381
Dyer WJ (1952) Amines in fish muscle. VI. Trimethylamine oxide content of fish and marine invertebrates. J Fish Res Board Can 8:314–324. https://doi.org/10.1139/f50-020
doi: 10.1139/f50-020
Cho CE, Taesuwan S, Malysheva OV, Bender E, Tulchinsky NF, Yan J, Sutter JL, Caudill MA (2017) Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial. Mol Nutr Food Res 61. http://www.ncbi.nlm.nih.gov/pubmed/27377678
Al-Waiz M, Mitchell SC, Idle JR, Smith RL (1987) The metabolism of 14C-labelled trimethylamine and its N-oxide in man. Xenobiotica 17:551–558
pubmed: 3604260
Brosnan ME, Brosnan JT (2016) The role of dietary creatine. Amino Acids 48:1785–1791
pubmed: 26874700
Abe H, Okuma E, Sekine H, Maeda A, Yoshiue S (1993) Human urinary excretion of L-histidine-related compounds after ingestion of several meats and fish muscle. Int J Biochem 25:1245–1249
pubmed: 8224369
Marliss EB, Wei CN, Dietrich LL (1979) The short-term effects of protein intake on 3-methylhistidine excretion. Am J Clin Nutr 32:1617–1621
pubmed: 463800
Agustsson I, Strom AR (1981) Biosynthesis and turnover of trimethylamine oxide in the teleost cod, Gadus morhua. J Biol Chem 256:8045–8049
pubmed: 7263638
Baker JR, Struempler A, Chaykin S (1963) A comparative study of trimethylamine-N-oxide biosynthesis. Biochim Biophys Acta 71:58–64
pubmed: 13969156
Fennema D, Phillips IR, Shephard EA (2016) Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease. Drug Metab Dispos 44:1839–1850
pubmed: 27190056
pmcid: 5074467
Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Luscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL (2018) Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. JCI Insight 3. http://www.ncbi.nlm.nih.gov/pubmed/29563342
Zeisel SH, Warrier M (2017) Trimethylamine N-oxide, the microbiome, and heart and kidney disease. Annu Rev Nutr 37:157–181
pubmed: 28715991
Abe H, Dobson GP, Hoeger U, Parkhouse WS (1985) Role of histidine-related compounds to intracellular buffering in fish skeletal muscle. Am J Physiol 249:R449–R454
pubmed: 4051030
USDA Food Composition Databases. https://ndb.nal.usda.gov/ndb/search/list . Accessed Sept 2016
Adeva-Andany M, Souto-Adeva G, Ameneiros-Rodriguez E, Fernandez-Fernandez C, Donapetry-Garcia C, Dominguez-Montero A (2018) Insulin resistance and glycine metabolism in humans. Amino Acids 50:11–27
pubmed: 29094215
Vikoren LA, Drotningsvik A, Mwakimonga A, Leh S, Mellgren G, Gudbrandsen OA (2018) Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. J Am Soc Hypertens 12:294–302
pubmed: 29472029