Matrix Metalloproteases as Influencers of the Cells' Social Media.
apoptosis
chemokine
cytokine
inflammation
interferon
invasion
matrix metalloproteinases (MMPs)
protease
proteomics
signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Aug 2019
07 Aug 2019
Historique:
received:
08
07
2019
revised:
01
08
2019
accepted:
02
08
2019
entrez:
10
8
2019
pubmed:
10
8
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their ability to increase cell invasion, and were initially thought to facilitate metastasis solely through the degradation of the extracellular matrix (ECM). MMPs have also been investigated in the context of their ECM remodeling activity in several acute and chronic inflammatory diseases. However, after several MMP inhibitors failed in phase III clinical trials, a global reassessment of their biological functions was undertaken, which has revealed multiple unanticipated functions including the processing of chemokines, cytokines, and cell surface receptors. Despite what their name suggests, the matrix aspect of MMPs could contribute to a lesser part of their physiological functions in inflammatory diseases, as originally anticipated. Here, we present examples of MMP substrates implicated in cell signaling, independent of their ECM functions, and discuss the impact for the use of MMP inhibitors.
Identifiants
pubmed: 31394726
pii: ijms20163847
doi: 10.3390/ijms20163847
pmc: PMC6720954
pii:
doi:
Substances chimiques
Cytokines
0
fas Receptor
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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