Hepatitis C Virus as a Unique Human Model Disease to Define Differences in the Transcriptional Landscape of T Cells in Acute versus Chronic Infection.
T cells
hepatitis C virus
metabolism
nucleosome
transcription factors
transcriptional regulation
viral hepatitis
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
26 07 2019
26 07 2019
Historique:
received:
27
06
2019
revised:
21
07
2019
accepted:
23
07
2019
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
26
9
2020
Statut:
epublish
Résumé
The hepatitis C virus is unique among chronic viral infections in that an acute outcome with complete viral elimination is observed in a minority of infected patients. This unique feature allows direct comparison of successful immune responses with those that fail in the setting of the same human infection. Here we review how this scenario can be used to achieve better understanding of transcriptional regulation of T-cell differentiation. Specifically, we discuss results from a study comparing transcriptional profiles of hepatitis C virus (HCV)-specific CD8 T-cells during early HCV infection between patients that do and do not control and eliminate HCV. Identification of early gene expression differences in key T-cell differentiation molecules as well as clearly distinct transcriptional networks related to cell metabolism and nucleosomal regulation reveal novel insights into the development of exhausted and memory T-cells. With additional transcriptional studies of HCV-specific CD4 and CD8 T-cells in different stages of infection currently underway, we expect HCV infection to become a valuable model disease to study human immunity to viruses.
Identifiants
pubmed: 31357397
pii: v11080683
doi: 10.3390/v11080683
pmc: PMC6723887
pii:
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : U19 AI082630
Pays : United States
Organisme : NIH HHS
ID : U01 AI131314
Pays : United States
Références
Gastroenterology. 1999 Oct;117(4):933-41
pubmed: 10500077
Cell. 2000 Mar 17;100(6):655-69
pubmed: 10761931
N Engl J Med. 2001 Jul 5;345(1):41-52
pubmed: 11439948
J Exp Med. 2001 Nov 19;194(10):1395-406
pubmed: 11714747
Science. 2002 Jan 11;295(5553):338-42
pubmed: 11786644
J Exp Med. 2003 Jun 16;197(12):1645-55
pubmed: 12810686
Science. 2003 Oct 24;302(5645):659-62
pubmed: 14576438
Gastroenterology. 2004 Sep;127(3):924-36
pubmed: 15362047
J Exp Med. 2004 Dec 20;200(12):1593-604
pubmed: 15611288
J Exp Med. 2005 Jun 6;201(11):1741-52
pubmed: 15939790
Hepatology. 2005 Jul;42(1):104-12
pubmed: 15962289
J Immunol. 2005 Sep 15;175(6):3603-13
pubmed: 16148104
J Virol. 2005 Oct;79(20):12979-88
pubmed: 16189000
J Biol Chem. 2006 Apr 28;281(17):11992-2000
pubmed: 16473879
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
J Virol. 2006 Nov;80(22):11398-403
pubmed: 16956940
J Immunol. 2006 Oct 15;177(8):4998-5005
pubmed: 17015682
Curr Opin Immunol. 2007 Aug;19(4):408-15
pubmed: 17656078
J Virol. 2008 Mar;82(6):3154-60
pubmed: 18160439
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15016-21
pubmed: 18809920
Genes Dev. 2008 Nov 1;22(21):2980-93
pubmed: 18981476
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Immunity. 2010 Jan 29;32(1):79-90
pubmed: 20096607
Blood. 2010 Nov 18;116(20):4274-83
pubmed: 20807888
Trends Mol Med. 2011 Jan;17(1):8-13
pubmed: 20971038
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14885-9
pubmed: 21873234
Cell Metab. 2011 Oct 5;14(4):443-51
pubmed: 21982705
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Immunity. 2012 Jan 27;36(1):68-78
pubmed: 22206904
J Exp Med. 2012 Jan 16;209(1):61-75
pubmed: 22213804
Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):270-6
pubmed: 22395772
Nat Immunol. 2012 Mar 11;13(4):405-11
pubmed: 22406686
Immunity. 2012 May 25;36(5):847-56
pubmed: 22464171
Immunity. 2012 Apr 20;36(4):542-50
pubmed: 22520847
Blood. 2012 Oct 25;120(17):3466-77
pubmed: 22955926
Immunity. 2012 Dec 14;37(6):1130-44
pubmed: 23159438
J Exp Med. 2012 Dec 17;209(13):2441-53
pubmed: 23183047
Science. 2012 Nov 30;338(6111):1220-5
pubmed: 23197535
Cell. 2013 Mar 28;153(1):56-69
pubmed: 23540690
Genes Dev. 2013 Apr 15;27(8):836-52
pubmed: 23630074
Nat Rev Cancer. 2013 Aug;13(8):572-83
pubmed: 23822983
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41
pubmed: 23940348
Cell Metab. 2013 Nov 5;18(5):617-33
pubmed: 23954639
Trends Immunol. 2014 Feb;35(2):51-60
pubmed: 24210163
Trends Immunol. 2014 Apr;35(4):178-85
pubmed: 24661777
Mol Cell. 2014 Apr 10;54(1):5-16
pubmed: 24725594
Nat Immunol. 2014 Oct;15(10):957-64
pubmed: 25194422
J Virol. 2015 Jan;89(1):25-34
pubmed: 25320295
J Biol Chem. 2014 Dec 5;289(49):34250-7
pubmed: 25331958
Cell. 2014 Nov 6;159(4):884-95
pubmed: 25417163
Nature. 2015 Feb 19;518(7539):413-6
pubmed: 25487152
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Nat Cell Biol. 2015 Apr;17(4):351-9
pubmed: 25774832
Cell Stem Cell. 2015 Apr 2;16(4):357-66
pubmed: 25842976
Curr Opin Cell Biol. 2015 Jun;34:69-74
pubmed: 26094239
Cell Stem Cell. 2015 Dec 3;17(6):651-662
pubmed: 26637942
Ann N Y Acad Sci. 2016 Jan;1363:91-8
pubmed: 26647078
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Nat Immunol. 2016 Jun;17(6):695-703
pubmed: 27111144
Trends Immunol. 2016 Aug;37(8):546-556
pubmed: 27402226
Nat Cell Biol. 2016 Aug;18(8):823-32
pubmed: 27428307
Cell Metab. 2016 Sep 13;24(3):485-493
pubmed: 27476976
Immunity. 2016 Aug 16;45(2):358-73
pubmed: 27496729
Nature. 2016 Aug 2;537(7620):412-428
pubmed: 27501245
Nature. 2016 Sep 15;537(7620):417-421
pubmed: 27501248
J Clin Invest. 2016 Sep 1;126(9):3479-94
pubmed: 27548527
Nat Rev Cancer. 2016 Nov;16(11):694-707
pubmed: 27634449
Nat Rev Immunol. 2016 Dec;16(12):741-750
pubmed: 27667712
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Science. 2016 Dec 2;354(6316):1165-1169
pubmed: 27789799
Nature. 2016 Dec 8;540(7632):236-241
pubmed: 27798602
Immunity. 2016 Dec 20;45(6):1270-1284
pubmed: 27939671
Immunity. 2016 Dec 20;45(6):1327-1340
pubmed: 27939672
Sci Immunol. 2016 Dec 23;1(6):null
pubmed: 28018990
Nat Med. 2017 Mar;23(3):327-336
pubmed: 28165481
Cell Stem Cell. 2017 Jul 6;21(1):135-143.e6
pubmed: 28366589
Front Immunol. 2017 Mar 27;8:316
pubmed: 28396661
J Exp Med. 2017 Jun 5;214(6):1593-1606
pubmed: 28490440
Nature. 2017 May 25;545(7655):452-456
pubmed: 28514453
Immunity. 2017 May 16;46(5):714-729
pubmed: 28514673
J Immunol. 2017 Aug 15;199(4):1213-1221
pubmed: 28784685
ILAR J. 2017 Dec 1;58(2):172-189
pubmed: 29045731
Immunity. 2017 Oct 17;47(4):648-663.e8
pubmed: 29045899
Immunity. 2018 Jan 16;48(1):161-173.e5
pubmed: 29305140
PLoS Pathog. 2018 Sep 17;14(9):e1007290
pubmed: 30222771
Viruses. 2018 Nov 17;10(11):
pubmed: 30453612
J Exp Med. 1998 May 4;187(9):1383-93
pubmed: 9565631
J Immunol. 1998 Feb 1;160(3):1479-88
pubmed: 9570570
J Exp Med. 1998 Dec 21;188(12):2205-13
pubmed: 9858507