Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study.

Adult Brain / diagnostic imaging Female Fluorine Radioisotopes Gray Matter / diagnostic imaging Humans Magnetic Resonance Imaging / methods Male Middle Aged Multiple Sclerosis, Chronic Progressive / diagnostic imaging Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging Pilot Projects Positron-Emission Tomography / methods

Journal

Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388

Informations de publication

Date de publication:
09 2019
Historique:
received: 19 11 2018
accepted: 15 05 2019
entrez: 30 7 2019
pubmed: 30 7 2019
medline: 25 9 2020
Statut: epublish

Résumé

To determine the value of [F-18]PBR06-PET for assessment of microglial activation in the cerebral gray matter in patients with MS. Twelve patients with MS (7 relapsing-remitting and 5 secondary progressive [SP]) and 5 healthy controls (HCs) had standardized uptake value (SUV) PET maps coregistered to 3T MRI and segmented into cortical and subcortical gray matter regions. SUV ratios (SUVRs) were global brain normalized. Voxel-by-voxel analysis was performed using statistical parametric mapping (SPM). Normalized brain parenchymal volumes (BPVs) were determined from MRI using SIENAX. Cortical SUVRs were higher in the hippocampus, amygdala, midcingulate, posterior cingulate, and rolandic operculum and lower in the medial-superior frontal gyrus and cuneus in the MS vs HC group (all This study suggests that [F-18]PBR06-PET detects widespread abnormal microglial activation in the cerebral gray matter in MS. Increased translocator protein binding in subcortical gray matter regions is associated with brain atrophy and may link to progressive MS.

Identifiants

DOI: 10.1212/NXI.0000000000000587 PMID: 31355321 PMC: PMC6624145
pubmed: 31355321
doi: 10.1212/NXI.0000000000000587
pii: NEURIMMINFL2018018754
pmc: PMC6624145
doi:

Substances chimiques

Fluorine Radioisotopes 0
Fluorine-18 GZ5I74KB8G

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e587

Références

Brain. 2000 Nov;123 ( Pt 11):2321-37
pubmed: 11050032
Ann Neurol. 2001 Sep;50(3):389-400
pubmed: 11558796
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
J Neurol Neurosurg Psychiatry. 1962 Nov;25:315-20
pubmed: 14016083
Magn Reson Med. 2006 Mar;55(3):478-83
pubmed: 16463353
J Neuropathol Exp Neurol. 2007 Sep;66(9):819-27
pubmed: 17805012
Brain Pathol. 2009 Apr;19(2):238-53
pubmed: 18492094
Ann Neurol. 2008 Sep;64(3):255-65
pubmed: 18661561
Cereb Cortex. 2009 Oct;19(10):2380-95
pubmed: 19188274
J Neuroimaging. 2009 Jan;19(1):3-8
pubmed: 19192042
Lancet Neurol. 2009 Mar;8(3):280-91
pubmed: 19233038
J Neuropathol Exp Neurol. 2009 May;68(5):489-502
pubmed: 19525897
Steroids. 2011 Nov;76(12):1331-40
pubmed: 21756927
Brain. 2011 Sep;134(Pt 9):2755-71
pubmed: 21840891
Neurology. 2012 Aug 7;79(6):523-30
pubmed: 22764258
Mol Imaging Biol. 2014 Feb;16(1):109-17
pubmed: 23836504
J Nucl Med. 2014 Jun;55(6):939-44
pubmed: 24711650
Neurology. 2014 Jul 15;83(3):278-86
pubmed: 24871874
J Nucl Med. 2015 Feb;56(2):311-6
pubmed: 25613536
Nat Rev Neurosci. 2015 Mar;16(3):147-58
pubmed: 25697158
Lancet Neurol. 2015 Feb;14(2):183-93
pubmed: 25772897
Neuroimage Clin. 2014 Dec 27;8:440-7
pubmed: 26106524
J Neuroimaging. 2016 Jan-Feb;26(1):62-7
pubmed: 26118637
Brain. 2016 Jan;139(Pt 1):115-26
pubmed: 26637488
Biol Psychiatry. 2016 Jul 1;80(1):62-72
pubmed: 26809249
JAMA Neurol. 2016 Aug 1;73(8):944-53
pubmed: 27294295
Ann Neurol. 2016 Nov;80(5):776-790
pubmed: 27686563
Neurol Ther. 2016 Dec;5(2):215-229
pubmed: 27744504
Int J Neurosci. 2017 Nov;127(11):971-980
pubmed: 28100092
Acta Neuropathol. 2017 Jul;134(1):15-34
pubmed: 28386765
J Clin Invest. 2017 Oct 2;127(10):3577-3587
pubmed: 28872464
Neuroimage. 2018 Feb 15;167:438-452
pubmed: 29097315
Semin Neurol. 2017 Oct;37(5):546-557
pubmed: 29207414
J Neuroimaging. 2018 Jan;28(1):36-47
pubmed: 29235194
Ann Neurol. 2018 Feb;83(2):223-234
pubmed: 29328531
Clin Nucl Med. 2018 Sep;43(9):e289-e295
pubmed: 30004939

Auteurs

Tarun Singhal (T)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Kelsey O'Connor (K)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Shipra Dubey (S)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Hong Pan (H)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Renxin Chu (R)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Shelley Hurwitz (S)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Steven Cicero (S)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
ORCID: 0000-0001-6425-5668

Shahamat Tauhid (S)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

David Silbersweig (D)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Emily Stern (E)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Marie Kijewski (M)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Marcelo DiCarli (M)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Howard L Weiner (HL)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Rohit Bakshi (R)

Partners MS Center (T.S., K.O.C., R.C., S.C., S.T., H.L.W., R.B.), Laboratory for Neuroimaging Research, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Division of Nuclear Medicine and Molecular Imaging (S.D., M.K., M.D.), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School; Functional Neuroimaging Laboratory (H.P., D.S., E.S.), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School; Department of Medicine (S.H.) and Department of Radiology (E.S., R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
ORCID: 0000-0001-8601-5534

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Gray matter microglial activation in relapsing...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Gray matter microglial activation in relapsing...
Recherchemedicale.com › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › Gray matter microglial activation in relapsing...
Recherchemedicale.com › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Gray matter microglial activation in relapsing...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gray matter microglial activation in relapsing...
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Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Sclérose en plaques chronique progressive › Gray matter microglial activation in relapsing...
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