Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery.
Co-morbidities
Diabetes
Hypertension
Microglia
Neuroinflammation
Neurovascualar Unit
Sex-differences
Stroke
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
09
04
2019
revised:
20
06
2019
accepted:
10
07
2019
pubmed:
18
7
2019
medline:
22
7
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Neuroinflammation underlies the etiology of multiple neurodegenerative diseases and stroke. Our understanding of neuroinflammation has evolved in the last few years and major players have been identified. Microglia, the brain resident macrophages, are considered sentinels at the forefront of the neuroinflammatory response to different brain insults. Interestingly, microglia perform other physiological functions in addition to their role in neuroinflammation. Therefore, an updated approach in which modulation, rather than complete elimination of microglia is necessary. In this review, the emerging roles of microglia and their interaction with different components of the neurovascular unit are discussed. In addition, recent data on sex differences in microglial physiology and in the context of stroke will be presented. Finally, the multiplicity of roles assumed by microglia in the pathophysiology of ischemic stroke, and in the presence of co-morbidities such as hypertension and diabetes are summarized.
Identifiants
pubmed: 31315064
pii: S1043-6618(19)30630-9
doi: 10.1016/j.phrs.2019.104349
pmc: PMC6954670
mid: NIHMS1535669
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104349Subventions
Organisme : BLRD VA
ID : I01 BX000347
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004471
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS083559
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104573
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
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