Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.

Autoantibodies Autoimmunity / physiology Biomarkers / blood CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Cell Line Child, Preschool Diabetes Mellitus, Type 1 / blood Disease Progression Early Diagnosis Female Humans Infant Insulin-Secreting Cells / immunology Male

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
10 2019
Historique:
received: 17 04 2019
accepted: 10 07 2019
pubmed: 18 7 2019
medline: 19 3 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

The appearance of type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. However, autoantibodies indicate an active autoimmune reaction, wherein the immune tolerance is already broken. Therefore, there is a clear and urgent need for new biomarkers that predict the onset of the autoimmune reaction preceding autoantibody positivity or reflect progressive β-cell destruction. Here we report the mRNA sequencing-based analysis of 306 samples including fractionated samples of CD4

Identifiants

DOI: 10.2337/db19-0287 PMID: 31311800
pubmed: 31311800
pii: db19-0287
doi: 10.2337/db19-0287
doi:

Substances chimiques

Autoantibodies 0
Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2024-2034

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2019 by the American Diabetes Association.

Auteurs

Henna Kallionpää (H)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Juhi Somani (J)

Department of Computer Science, Aalto University School of Science, Espoo, Finland.

Soile Tuomela (S)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Ubaid Ullah (U)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
ORCID: 0000-0002-2539-2296

Rafael de Albuquerque (R)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Tapio Lönnberg (T)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Elina Komsi (E)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Heli Siljander (H)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Jarno Honkanen (J)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Taina Härkönen (T)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Aleksandr Peet (A)

Department of Pediatrics, University of Tartu, Tartu, Estonia.
Children's Clinic of Tartu, Tartu University Hospital, Tartu, Estonia.

Vallo Tillmann (V)

Department of Pediatrics, University of Tartu, Tartu, Estonia.
Children's Clinic of Tartu, Tartu University Hospital, Tartu, Estonia.

Vikash Chandra (V)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Mahesh Kumar Anagandula (MK)

Department of Immunology, Genetics and Pathology, Uppsala University, Sweden.

Gun Frisk (G)

Department of Immunology, Genetics and Pathology, Uppsala University, Sweden.

Timo Otonkoski (T)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0001-9190-2496

Omid Rasool (O)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Riikka Lund (R)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Harri Lähdesmäki (H)

Department of Computer Science, Aalto University School of Science, Espoo, Finland.

Mikael Knip (M)

Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Folkhälsan Research Center, Helsinki, Finland.
Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.
ORCID: 0000-0003-0474-0033

Riitta Lahesmaa (R)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland riitta.lahesmaa@utu.fi.
ORCID: 0000-0002-4782-9567

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunité › Auto-immunité › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Cellules › Cellules cultivées › Lignée cellulaire › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Diagnostic › Diagnostic précoce › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Personnes › Tranches d'âge › Nourrisson › Early Detection of Peripheral Blood Cell...
Recherchemedicale.com › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Early Detection of Peripheral Blood Cell...