Differential response of esophageal cancer cells to particle irradiation.
Carbon ion radiation
Esophageal cancer
Heavy ion radiotherapy
Proton radiation
Journal
Radiation oncology (London, England)
ISSN: 1748-717X
Titre abrégé: Radiat Oncol
Pays: England
ID NLM: 101265111
Informations de publication
Date de publication:
08 Jul 2019
08 Jul 2019
Historique:
received:
31
01
2019
accepted:
26
06
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the still poor prognosis of many EC patients, particle radiation employing a higher biological effectiveness may help to further improve patient outcomes. However, the influence of clinically available particle radiation on EC cells remains largely unknown. Patient-derived esophageal adenocarcinoma and squamous cell cancer lines were treated with photon and particle irradiation using clinically available proton ( While both adenocarcinoma EC cell lines demonstrated increasing sensitivities for Esophageal cancer cells exhibit differential responses to irradiation with photons and
Sections du résumé
BACKGROUND
BACKGROUND
Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the still poor prognosis of many EC patients, particle radiation employing a higher biological effectiveness may help to further improve patient outcomes. However, the influence of clinically available particle radiation on EC cells remains largely unknown.
METHODS
METHODS
Patient-derived esophageal adenocarcinoma and squamous cell cancer lines were treated with photon and particle irradiation using clinically available proton (
RESULTS
RESULTS
While both adenocarcinoma EC cell lines demonstrated increasing sensitivities for
CONCLUSIONS
CONCLUSIONS
Esophageal cancer cells exhibit differential responses to irradiation with photons and
Identifiants
pubmed: 31286978
doi: 10.1186/s13014-019-1326-9
pii: 10.1186/s13014-019-1326-9
pmc: PMC6615091
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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