Fatigue in primary Sjögren's syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study.
Cytokines
Fatigue
Primary Sjögren’s syndrome
Proinflammatory
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
09
04
2019
accepted:
18
06
2019
pubmed:
30
6
2019
medline:
28
4
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
Primary Sjögren's syndrome (pSS) is a chronic autoimmune rheumatic disease with symptoms including dryness, fatigue, and pain. The previous work by our group has suggested that certain proinflammatory cytokines are inversely related to patient-reported levels of fatigue. To date, these findings have not been validated. This study aims to validate this observation. Blood levels of seven cytokines were measured in 120 patients with pSS from the United Kingdom Primary Sjögren's Syndrome Registry and 30 age-matched healthy non-fatigued controls. Patient-reported scores for fatigue were classified according to severity and compared to cytokine levels using analysis of variance. The differences between cytokines in cases and controls were evaluated using Wilcoxon test. A logistic regression model was used to determine the most important identifiers of fatigue. Five cytokines, interferon-γ-induced protein-10 (IP-10), tumour necrosis factor-α (TNFα), interferon-α (IFNα), interferon-γ (IFN-γ), and lymphotoxin-α (LT-α) were significantly higher in patients with pSS (n = 120) compared to non-fatigued controls (n = 30). Levels of two proinflammatory cytokines, TNF-α (p = 0.021) and LT-α (p = 0.043), were inversely related to patient-reported levels of fatigue. Cytokine levels, disease-specific and clinical parameters as well as pain, anxiety, and depression were used as predictors in our validation model. The model correctly identifies fatigue levels with 85% accuracy. Consistent with the original study, pain, depression, and proinflammatory cytokines appear to be the most powerful predictors of fatigue in pSS. TNF-α and LT-α have an inverse relationship with fatigue severity in pSS challenging the notion that proinflammatory cytokines directly mediate fatigue in chronic immunological conditions.
Identifiants
pubmed: 31250166
doi: 10.1007/s00296-019-04354-0
pii: 10.1007/s00296-019-04354-0
pmc: PMC6791914
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1867-1873Subventions
Organisme : Medical Research Council
ID : MR/J002720/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800629
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21183
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21233
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003063/1
Pays : United Kingdom
Investigateurs
Frances Hall
(F)
Elalaine C Bacabac
(EC)
Helen Frankland
(H)
Robert Moots
(R)
Kuntal Chadravarty
(K)
Shamin Lamabadusuriya
(S)
Michele Bombardieri
(M)
Constantino Pitzalis
(C)
Nurhan Sutcliffe
(N)
Celia Breston
(C)
Nagui Gendi
(N)
Karen Culfear
(K)
Claire Riddell
(C)
John Hamburger
(J)
Andrea Richards
(A)
Saaeha Rauz
(S)
Sue Brailsford
(S)
Joanne Dasgin
(J)
Joanne Logan
(J)
Diarmuid Mulherin
(D)
Jacqueline Andrews
(J)
Paul Emery
(P)
Alison McManus
(A)
Colin Pease
(C)
David Pickles
(D)
Alison Booth
(A)
Marian Regan
(M)
Jon King
(J)
Amanda Holt
(A)
Theodoros Dimitroulas
(T)
Lucy Kadiki
(L)
Daljit Kaur
(D)
George Kitas
(G)
Abdul Khan
(A)
Tracey Cosier
(T)
None Panthakalam
Kelly Mintrim
(K)
Mark Lloyd
(M)
Lisa Moore
(L)
Esther Gordon
(E)
Cathy Lawson
(C)
Monica Gupta
(M)
John Hunter
(J)
Lesley Stirton
(L)
Gill Ortiz
(G)
Elizabeth Price
(E)
Suzannah Pelger
(S)
Claire Gorman
(C)
Balinder Hans
(B)
Gavin Clunie
(G)
Suzanne Lane
(S)
Ginny Rose
(G)
Sue Cuckow
(S)
Michael Batley
(M)
Ruby Einosas
(R)
Susan Knight
(S)
Deborah Symmons
(D)
Beverley Jones
(B)
Andrew Carr
(A)
Suzanne Edgar
(S)
Francisco Figuereido
(F)
Heather Foggo
(H)
Dennis Lendrem
(D)
Iain Macleod
(I)
Sheryl Mitchell
(S)
Christine Downie
(C)
Jessica Tarn
(J)
James Locke
(J)
Shereen Al-Ali
(S)
Sarah Legg
(S)
Kamran Mirza
(K)
Ben Hargreaves
(B)
Laura Hetherington
(L)
Adrian Jones
(A)
Peter Lanyon
(P)
Alice Muir
(A)
Paula White
(P)
Steven Young-Min
(S)
Susan Pugmire
(S)
Saravanan Vadivelu
(S)
Annie Cooper
(A)
Marianne Watkins
(M)
Anne Field
(A)
Stephen Kaye
(S)
Devesh Mewar
(D)
Patricia Medcalf
(P)
Pamela Tomlinson
(P)
Debbie Whiteside
(D)
Neil McHugh
(N)
John Pauling
(J)
Julie James
(J)
Andrea Dowden
(A)
Mohammed Akil
(M)
Jayne McDermott
(J)
Olivia Godia
(O)
David Coady
(D)
Elizabeth Kidd
(E)
Lynne Palmer
(L)
Charles Li
(C)
Sarah Bartrum
(S)
Dee Mead
(D)
Bhaskar Dasgupta
(B)
Victoria Katsande
(V)
Pamela Long
(P)
Olivia Godia
(O)
Erin Vermaak
(E)
Janet Turner
(J)
Usha Chandra
(U)
Kirsten MacKay
(K)
Stefano Fedele
(S)
Ada Ferenkeh-Koroma
(A)
Ian Giles
(I)
David Isenberg
(D)
Helena MaConnell
(H)
Nyarko Ahwireng
(N)
Stephen Porter
(S)
Paul Allcoat
(P)
John McLaren
(J)
Références
Rheumatology (Oxford). 2018 May 1;57(5):921-930
pubmed: 29474655
Rheumatology (Oxford). 2010 May;49(5):844-53
pubmed: 20147445
J Psychosom Res. 2002 Feb;52(2):69-77
pubmed: 11832252
Clin Exp Immunol. 2004 Feb;135(2):294-302
pubmed: 14738459
Rheumatology (Oxford). 2009 Sep;48(9):1077-82
pubmed: 19553376
Rheumatology (Oxford). 2011 Jan;50(1):32-9
pubmed: 20693261
RMD Open. 2016 Jul 19;2(2):e000282
pubmed: 27493792
Ann Rheum Dis. 2010 Jun;69(6):1103-9
pubmed: 19561361
J Affect Disord. 2012 Dec 10;141(2-3):130-42
pubmed: 22578888
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3372-7
pubmed: 15728381
Arthritis Rheum. 2004 Apr;50(4):1270-6
pubmed: 15077311
Ir J Med Sci. 2002 Jan-Mar;171(1):10-2
pubmed: 11993585
J Psychosom Res. 2002 Jun;52(6):445-52
pubmed: 12069868
Arthritis Res Ther. 2011;13(5):R167
pubmed: 21996338
Ann Rheum Dis. 2011 Jun;70(6):968-72
pubmed: 21345815
Cost Eff Resour Alloc. 2004 Jun 21;2(1):4
pubmed: 15210053
Scand J Public Health. 2005;33(2):123-30
pubmed: 15823973