The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Acute Disease
Animals
CA-19-9 Antigen
/ immunology
Carcinogenesis
/ metabolism
Carcinoma, Pancreatic Ductal
/ metabolism
Cell Line, Tumor
Chronic Disease
ErbB Receptors
/ metabolism
Extracellular Matrix Proteins
/ metabolism
Fucosyltransferases
/ genetics
Galactosyltransferases
/ genetics
Glycosylation
Humans
Mice
Molecular Targeted Therapy
/ methods
Pancreatic Neoplasms
/ metabolism
Pancreatitis
/ metabolism
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
08
12
2018
revised:
25
03
2019
accepted:
14
05
2019
entrez:
22
6
2019
pubmed:
22
6
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expressed human fucosyltransferase 3 and β1,3-galactosyltransferase 5 in mice, reconstituting the glycan sialyl-Lewis
Identifiants
pubmed: 31221853
pii: 364/6446/1156
doi: 10.1126/science.aaw3145
pmc: PMC6705393
mid: NIHMS1043750
doi:
Substances chimiques
CA-19-9 Antigen
0
Efemp1 protein, mouse
0
Extracellular Matrix Proteins
0
B3GALT5 protein, human
EC 2.4.1.-
Fucosyltransferases
EC 2.4.1.-
Galactosyltransferases
EC 2.4.1.-
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
EC 2.4.1.65
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1156-1162Subventions
Organisme : NCI NIH HHS
ID : P20 CA192996
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188134
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190092
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA192994
Pays : United States
Organisme : NIH HHS
ID : S10 OD018338
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA101955
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA204725
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127297
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180944
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA045508
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA148056
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA217798
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA204725
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211506
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA210240
Pays : United States
Organisme : NIH HHS
ID : S10 OD010580
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Genes Dev. 2001 Dec 15;15(24):3243-8
pubmed: 11751630
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
Cancer Cell. 2003 Dec;4(6):437-50
pubmed: 14706336
Scand J Gastroenterol Suppl. 2003;(239):117-22
pubmed: 14743894
Mol Cell Biol. 2004 Oct;24(19):8586-99
pubmed: 15367678
Genesis. 2006 Jan;44(1):23-8
pubmed: 16400644
Cell. 1990 Jun 15;61(6):1121-35
pubmed: 1693546
Biochem Biophys Res Commun. 1991 Sep 16;179(2):713-9
pubmed: 1716885
Cancer Cell. 2007 Mar;11(3):291-302
pubmed: 17349585
Lancet. 2008 Jan 12;371(9607):143-52
pubmed: 18191686
Cancer Sci. 2008 Aug;99(8):1611-7
pubmed: 18754874
Arch Pathol Lab Med. 2009 Mar;133(3):382-7
pubmed: 19260744
Anal Biochem. 2009 Apr 15;387(2):162-70
pubmed: 19454239
Immunol Rev. 2009 Jul;230(1):97-113
pubmed: 19594631
Biol Chem. 2009 Dec;390(12):1293-302
pubmed: 19804359
Clin Cancer Res. 2011 Mar 1;17(5):1024-32
pubmed: 21343375
J Biol Chem. 2011 Jul 15;286(28):25256-64
pubmed: 21596743
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11332-7
pubmed: 21709263
Proteomics. 2011 Sep;11(18):3665-74
pubmed: 21751362
PLoS One. 2011;6(12):e29180
pubmed: 22220206
Cancer Cell. 2012 Sep 11;22(3):304-17
pubmed: 22975374
Cancer Cell. 2012 Sep 11;22(3):318-30
pubmed: 22975375
Gastroenterology. 2013 Jun;144(6):1252-61
pubmed: 23622135
Gastroenterology. 1986 Feb;90(2):343-9
pubmed: 2416628
Arch Pathol Lab Med. 2014 Feb;138(2):220-8
pubmed: 24476519
PLoS One. 2014 Apr 17;9(4):e95236
pubmed: 24743474
World J Gastroenterol. 2014 Aug 28;20(32):11160-81
pubmed: 25170202
Cell. 2015 Jan 15;160(1-2):324-38
pubmed: 25557080
Mol Cell Proteomics. 2015 May;14(5):1323-33
pubmed: 25733690
Curr Opin Gastroenterol. 2015 Sep;31(5):395-9
pubmed: 26107390
Nat Rev Cancer. 2015 Sep;15(9):540-55
pubmed: 26289314
Int J Clin Exp Med. 2015 Jul 15;8(7):11683-91
pubmed: 26380005
Pancreatology. 2016 Mar-Apr;16(2):218-24
pubmed: 26924663
Lancet. 2016 May 7;387(10031):1957-66
pubmed: 26948434
Nucleic Acids Res. 2016 Dec 15;44(22):11033
pubmed: 27683222
N Engl J Med. 2016 Nov 17;375(20):1972-1981
pubmed: 27959604
Mayo Clin Proc. 2017 Mar;92(3):434-448
pubmed: 28160947
BMC Med. 2017 Feb 10;15(1):29
pubmed: 28183317
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;51(6):535-44
pubmed: 2878526
Cancer Discov. 2018 Sep;8(9):1112-1129
pubmed: 29853643
Br J Cancer. 2018 Jun;118(12):1609-1616
pubmed: 29872151
Gastroenterology. 1986 Sep;91(3):576-80
pubmed: 3015709
Cancer Res. 1988 Jul 1;48(13):3834-42
pubmed: 3288336
Pancreas. 1987;2(4):398-403
pubmed: 3306667
Gastroenterology. 1987 Jan;92(1):60-7
pubmed: 3465666
Br J Cancer. 1986 Feb;53(2):189-95
pubmed: 3513813
Cancer Res. 1993 Jan 15;53(2):354-61
pubmed: 7678075
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1515-9
pubmed: 7878011
N Engl J Med. 1993 May 20;328(20):1433-7
pubmed: 8479461
N Engl J Med. 1996 Sep 26;335(13):909-18
pubmed: 8782497
Science. 1996 Dec 20;274(5295):2086-9
pubmed: 8953040
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14821-6
pubmed: 9843973