Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank.
Journal
American heart journal
ISSN: 1097-6744
Titre abrégé: Am Heart J
Pays: United States
ID NLM: 0370465
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
23
12
2018
accepted:
26
04
2019
pubmed:
17
6
2019
medline:
7
3
2020
entrez:
17
6
2019
Statut:
ppublish
Résumé
Glomerular filtration rate is a key physiologic variable with a central role in clinical decision making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disease (ACHD). We conducted a prospective cohort study of outpatient ACHD ≥18 years old seen in 2012-2017. Creatinine and cystatin C were measured; eGFR was calculated using either the creatinine or cystatin C Chronic Kidney Disease-Epidemiology Collaboration equation (CKD-EPI Our cohort included 911 ACHD (39 ± 14 years old, 49% female). Mean CKD-EPI Cystatin C-based eGFR more strongly predicts clinical events than creatinine-based eGFR in ACHD. Creatinine-based methods appear particularly questionable in the Fontan circulation.
Sections du résumé
BACKGROUND
Glomerular filtration rate is a key physiologic variable with a central role in clinical decision making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disease (ACHD).
METHODS
We conducted a prospective cohort study of outpatient ACHD ≥18 years old seen in 2012-2017. Creatinine and cystatin C were measured; eGFR was calculated using either the creatinine or cystatin C Chronic Kidney Disease-Epidemiology Collaboration equation (CKD-EPI
RESULTS
Our cohort included 911 ACHD (39 ± 14 years old, 49% female). Mean CKD-EPI
CONCLUSIONS
Cystatin C-based eGFR more strongly predicts clinical events than creatinine-based eGFR in ACHD. Creatinine-based methods appear particularly questionable in the Fontan circulation.
Identifiants
pubmed: 31203159
pii: S0002-8703(19)30107-3
doi: 10.1016/j.ahj.2019.04.018
pii:
doi:
Substances chimiques
Biomarkers
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-155Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.