Directional kinetics analysis of the progression of geographic atrophy.
Euclidean distance map
Fundus autofluorescence
Geographic atrophy
Progression rate
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
30
11
2018
accepted:
20
05
2019
revised:
07
05
2019
pubmed:
31
5
2019
medline:
7
8
2019
entrez:
1
6
2019
Statut:
ppublish
Résumé
To investigate the influence of baseline geographic atrophy (GA) size on the rate of GA progression by using both distance and area measurements. Thirty-five eyes from 24 patients with GA due to age-related macular degeneration were obtained from anonymized datasets available at the Doheny Image Reading Center. Baseline and month 12 fundus autofluorescence (FAF) images were used for this analysis. Borders of GA lesions were semiautomatically segmented by certified reading center graders to create masks of the GA lesion. The masks from the two visits were registered and overlaid to allow the differences in area as well as the differences in the position of GA border between the visits to be computed. Distance measurements were performed using a Euclidean distance map. Sectoral (clock hour)/directional GA progression rates with respect to the foveal center were also calculated. GA progressed 1.6 ± 0.9 mm Use of linear distance-based measurements enables evaluation of GA progression which is not confounded by baseline lesion size.
Identifiants
pubmed: 31147841
doi: 10.1007/s00417-019-04368-1
pii: 10.1007/s00417-019-04368-1
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1679-1685Références
Ophthalmology. 1999 Sep;106(9):1768-79
pubmed: 10485549
Arch Ophthalmol. 2003 Nov;121(11):1621-4
pubmed: 14609922
Arch Ophthalmol. 2004 Apr;122(4):564-72
pubmed: 15078675
Ophthalmology. 2007 Feb;114(2):271-7
pubmed: 17270676
Arch Ophthalmol. 2009 Sep;127(9):1168-74
pubmed: 19752426
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1691-8
pubmed: 19907024
Ophthalmology. 2011 Apr;118(4):679-86
pubmed: 21035861
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6241-5
pubmed: 21444807
Retina. 2013 Mar;33(3):498-507
pubmed: 23023528
JAMA Ophthalmol. 2013 Jan;131(1):110-1
pubmed: 23307222
Invest Ophthalmol Vis Sci. 2013 Apr 26;54(4):2941-50
pubmed: 23548622
Ophthalmology. 2014 May;121(5):1079-91
pubmed: 24433969
PLoS One. 2014 Feb 26;9(2):e89679
pubmed: 24586959
Ophthalmology. 2016 Nov;123(11):2401-2407
pubmed: 27448832
Ophthalmology. 2017 Feb;124(2):215-223
pubmed: 27863845
Retina. 2018 Feb;38(2):272-282
pubmed: 28221256
Br J Ophthalmol. 2018 Jan;102(1):109-113
pubmed: 28495907
Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4792-4798
pubmed: 28973325
Ophthalmology. 2018 Mar;125(3):369-390
pubmed: 29110945
Retina. 2018 Oct;38(10):1930-1936
pubmed: 29160788
Retina. 2018 May 16;:null
pubmed: 29781974
Ophthalmology. 2018 Dec;125(12):1913-1928
pubmed: 30060980
Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4143-4153
pubmed: 30105369
PLoS One. 2018 Aug 23;13(8):e0201599
pubmed: 30138396
Arch Ophthalmol. 1995 Mar;113(3):333-9
pubmed: 7887847
Biometrics. 1977 Mar;33(1):159-74
pubmed: 843571