The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.

Carcinogenesis Endometrial Neoplasms Female Humans Mutation Neoplasm Recurrence, Local Protein Phosphatase 2 / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
15 Aug 2019
Historique:
received: 17 01 2019
revised: 12 04 2019
accepted: 22 05 2019
pubmed: 31 5 2019
medline: 27 8 2019
entrez: 31 5 2019
Statut: ppublish

Résumé

Somatic mutation of the protein phosphatase 2A (PP2A) Aα-subunit gene

Identifiants

DOI: 10.1158/0008-5472.CAN-19-0218 PMID: 31142515 PMC: PMC6724736
pubmed: 31142515
pii: 0008-5472.CAN-19-0218
doi: 10.1158/0008-5472.CAN-19-0218
pmc: PMC6724736
mid: NIHMS1530492
doi:

Substances chimiques

Protein Phosphatase 2 EC 3.1.3.16

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4242-4257

Subventions

Organisme : NCI NIH HHS
ID : F30 CA224979
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL068863
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR031845
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008803
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240993
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA224977
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002547
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA181654
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002549
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL107147
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130209
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL081064
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA138421
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA197780
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR018390
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL103453
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2019 American Association for Cancer Research.

Références

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Auteurs

Sarah E Taylor (SE)

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Caitlin M O'Connor (CM)

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
ORCID: 0000-0002-7840-6399

Zhizhi Wang (Z)

Department of Biological Structure, University of Washington, Seattle, Washington.

Guobo Shen (G)

Department of Biological Structure, University of Washington, Seattle, Washington.

Haichi Song (H)

Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, London, United Kingdom.

Daniel Leonard (D)

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Jaya Sangodkar (J)

Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Corinne LaVasseur (C)

School of Medicine, Case Western Reserve University, Cleveland, Ohio.

Stefanie Avril (S)

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

Steven Waggoner (S)

Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Cleveland, Ohio.

Kristine Zanotti (K)

Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Cleveland, Ohio.
ORCID: 0000-0002-4712-2852

Amy J Armstrong (AJ)

Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Cleveland, Ohio.
ORCID: 0000-0002-5437-7319

Christa Nagel (C)

Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Cleveland, Ohio.

Kimberly Resnick (K)

Department of Obstetrics and Gynecology, MetroHealth, Cleveland, Ohio.

Sareena Singh (S)

Department of Obstetrics and Gynecology, Aultman Hospital, Canton, Ohio.

Mark W Jackson (MW)

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

Wenqing Xu (W)

Department of Biological Structure, University of Washington, Seattle, Washington.

Shozeb Haider (S)

Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, London, United Kingdom.

Analisa DiFeo (A)

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Department of Pathology, University of Michigan, Ann Arbor, Michigan.
Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.
ORCID: 0000-0001-8319-6763

Goutham Narla (G)

Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. gnarla@med.umich.edu.
Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.

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Classifications MeSH

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Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein Phosphatase 2 › The Highly Recurrent PP2A Aα-Subunit Mutation...