Recurrent venous thrombosis during direct oral anticoagulant therapy in a patient with protein S deficiency.


Journal

The journal of medical investigation : JMI
ISSN: 1349-6867
Titre abrégé: J Med Invest
Pays: Japan
ID NLM: 9716841

Informations de publication

Date de publication:
2019
Historique:
entrez: 9 5 2019
pubmed: 9 5 2019
medline: 18 12 2019
Statut: ppublish

Résumé

Protein S (PS) deficiency is an inherited thrombophilia associated with an increased risk of venous thromboembolism (VTE). In Japan, unfractionated heparin followed by warfarin has been historically applied for the treatment of VTE. Recent evidence showed that direct oral anticoagulants (DOACs) were non-inferior to standard therapy with warfarin, with significantly less bleeding in patients with VTE. However, it is unknown whether DOACs are effective for the treatment of VTE in patients with thrombophilia, including protein S deficiency, due to lack of evidence. Here, we report a case of recurrent venous thrombosis during edoxaban therapy in a patient with protein S deficiency, which was successfully treated using high-dose apixaban therapy. J.Med. Invest. 66 : 182-184, February, 2019.

Identifiants

pubmed: 31064935
doi: 10.2152/jmi.66.182
doi:

Substances chimiques

Anticoagulants 0
Pyrazoles 0
Pyridines 0
Pyridones 0
Thiazoles 0
apixaban 3Z9Y7UWC1J
edoxaban NDU3J18APO

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

182-184

Auteurs

Shusuke Yagi (S)

Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Department of Community Medicine and Human Resource Development, Tokushima University Graduate School of Biomedical Sciences, Tokushima,Japan.

Kumiko Kagawa (K)

Department of Hematology, Endocrinology and Metabolism, Tokushima, Japan.

Eiki Fujimoto (E)

Department of Cardiovascular Surgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

Masataka Sata (M)

Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

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Classifications MeSH