High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A Double-Blind Randomized Clinical Trial.
Functional performance
Metabolism
Preventative health care
Sarcopenia
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
25
09
2018
pubmed:
6
5
2019
medline:
17
6
2020
entrez:
7
5
2019
Statut:
ppublish
Résumé
The age-related decline in mass, strength, and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization, and death. To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle-aged and older subjects, we conducted a two-phase, randomized, double-blind, clinical trial. The initial study included 60 subjects (55- to 70-year-old) allocated into placebo (P), highly alkalinized (no-flavonoid; NF), or flavonoid-rich natural cocoa (F) beverage groups. The follow-up study included 74 older subjects (65- to 90-year-old) randomly distributed into NF or F groups. Subjects were instructed to consume the beverages once/day for up to 12-weeks. A comprehensive (aging relevant) set of end points were assessed, which included mean change in blood plasma metabolic and oxidative stress indicators, in physical performance tests and quality of life (QoL). In the initial study, the F group showed improved glycemia, triglyceridemia, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, triglyceridemia/HDL index, and oxidative markers. Performance on the Up and Go test, skeletal muscle index, and quality of life also improved. In the follow-up study, F treatment was associated with significant improvements in metabolic, oxidative stress, and inflammatory endpoints and positive effects on physical performance, frailty indicators, and quality of life (F vs. NF group). Regular flavonoids consumption positively affects blood oxidative stress and inflammation end points, cardiometabolic risk markers, physical performance, and quality of life. The sum of such effects may help to mitigate the extent of frailty development in the elderly people. NCT03585868.
Sections du résumé
BACKGROUND
The age-related decline in mass, strength, and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization, and death.
METHODS
To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle-aged and older subjects, we conducted a two-phase, randomized, double-blind, clinical trial. The initial study included 60 subjects (55- to 70-year-old) allocated into placebo (P), highly alkalinized (no-flavonoid; NF), or flavonoid-rich natural cocoa (F) beverage groups. The follow-up study included 74 older subjects (65- to 90-year-old) randomly distributed into NF or F groups. Subjects were instructed to consume the beverages once/day for up to 12-weeks. A comprehensive (aging relevant) set of end points were assessed, which included mean change in blood plasma metabolic and oxidative stress indicators, in physical performance tests and quality of life (QoL).
RESULTS
In the initial study, the F group showed improved glycemia, triglyceridemia, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, triglyceridemia/HDL index, and oxidative markers. Performance on the Up and Go test, skeletal muscle index, and quality of life also improved. In the follow-up study, F treatment was associated with significant improvements in metabolic, oxidative stress, and inflammatory endpoints and positive effects on physical performance, frailty indicators, and quality of life (F vs. NF group).
CONCLUSIONS
Regular flavonoids consumption positively affects blood oxidative stress and inflammation end points, cardiometabolic risk markers, physical performance, and quality of life. The sum of such effects may help to mitigate the extent of frailty development in the elderly people.
TRIAL REGISTRATION
NCT03585868.
Identifiants
pubmed: 31056655
pii: 5485921
doi: 10.1093/gerona/glz107
pmc: PMC6748722
doi:
Substances chimiques
Flavonoids
0
Banques de données
ClinicalTrials.gov
['NCT03585868']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1620-1627Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Lancet. 2002 Oct 26;360(9342):1323-5
pubmed: 12414225
J Gerontol A Biol Sci Med Sci. 2006 Oct;61(10):1059-64
pubmed: 17077199
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65
pubmed: 17167156
Clin Physiol Funct Imaging. 2007 Mar;27(2):91-100
pubmed: 17309529
BMJ. 2008 Jul 01;337:a439
pubmed: 18595904
Methods Enzymol. 1990;186:464-78
pubmed: 1978225
Age Ageing. 2010 Mar;39(2):169-75
pubmed: 20097661
Int J Behav Nutr Phys Act. 2010 May 11;7:38
pubmed: 20459782
J Clin Lipidol. 2010 Mar-Apr;4(2):89-98
pubmed: 21122635
J Cachexia Sarcopenia Muscle. 2010 Dec;1(2):129-133
pubmed: 21475695
J Physiol. 2011 Sep 15;589(Pt 18):4615-31
pubmed: 21788351
Eur J Appl Physiol. 2012 Apr;112(4):1335-47
pubmed: 21796409
Clin Chem Lab Med. 2012 Feb 01;50(8):1287-95
pubmed: 22868792
Ageing Res Rev. 2013 Jan;12(1):329-38
pubmed: 23063488
Clin Sci (Lond). 2013 Jun;124(11):663-74
pubmed: 23252598
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
Int J Cardiol. 2013 Oct 9;168(4):3982-3990
pubmed: 23870648
Prev Med. 2014 Feb;59:68-72
pubmed: 24291684
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1370-8
pubmed: 25143004
Clin Cases Miner Bone Metab. 2014 Sep;11(3):215-21
pubmed: 25568656
Pol Arch Med Wewn. 2015;125(1-2):18-26
pubmed: 25578383
Biogerontology. 2016 Jun;17(3):567-80
pubmed: 26936444
Exp Gerontol. 2016 Jun 15;79:55-60
pubmed: 27032304
Oxid Med Cell Longev. 2016;2016:3565127
pubmed: 27247702
Food Funct. 2016 Sep 14;7(9):3686-93
pubmed: 27491778
PLoS One. 2016 Aug 08;11(8):e0160019
pubmed: 27500953
J Nutr. 2016 Nov;146(11):2325-2333
pubmed: 27683874
FASEB J. 2019 Jan;33(1):965-977
pubmed: 30096038
J Aging Phys Act. 2019 Jun 1;27(3):384-391
pubmed: 30299198
J Neurol Sci. 1988 Apr;84(2-3):275-94
pubmed: 3379447
Chem Res Toxicol. 1998 Oct;11(10):1176-83
pubmed: 9778314