Long non-coding RNAs and cell death following ischemic stroke.


Journal

Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370

Informations de publication

Date de publication:
10 2019
Historique:
received: 23 01 2019
accepted: 21 04 2019
pubmed: 6 5 2019
medline: 1 5 2020
entrez: 6 5 2019
Statut: ppublish

Résumé

Stroke is a major cause of morbidity and mortality worldwide, and extensive efforts have focused on the improvement of therapeutic strategies to reduce cell death following ischemic stroke. Uncovering the cellular and molecular pathophysiological processes in ischemic stroke have been a top priority. Long noncoding RNAs (lncRNAs) are endogenous molecules that play key roles in the pathophysiology of cerebral ischemia, and involved in the neuronal cell death during ischemic stroke. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke insulted animals. LncRNAs along with their targets could affect the genetic machinery at molecular levels, and exploring their functions and mechanisms may be a promising option for ischemic stroke treatment. In this review, we summarize the current knowledge for lncRNAs in ischemic stroke, focusing on the role of specific lncRNAs that may underlie cell death to find possible therapeutic targets.

Identifiants

pubmed: 31055786
doi: 10.1007/s11011-019-00423-2
pii: 10.1007/s11011-019-00423-2
doi:

Substances chimiques

RNA, Long Noncoding 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1243-1251

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Auteurs

Masoumeh Alishahi (M)

Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.

Farhoodeh Ghaedrahmati (F)

Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Tannaz Akbari Kolagar (TA)

Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.

William Winlow (W)

Dipartimento di Biologia, Università degli Studi di Napoli, Federico II, Via Cintia 26, 80126, Naples, Italy.
Honorary Research Fellow, Institute of Ageing and Chronic Diseases, University of Liverpool, The APEX building, 6 West Derby Street, Liverpool, L7 8TX, UK.

Negin Nikkar (N)

Department of Biology, Faculty of Sciences, Alzahra University, Tehran, Iran.

Maryam Farzaneh (M)

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Seyed Esmaeil Khoshnam (SE)

Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Esmaeil.khoshnam1392@gmail.com.

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Classifications MeSH