Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light.
Functional pain syndromes
diffuse hypersensitivity
injury free
red light-emitting diode
widespread pain
Journal
The journal of pain
ISSN: 1528-8447
Titre abrégé: J Pain
Pays: United States
ID NLM: 100898657
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
08
11
2018
revised:
23
02
2019
accepted:
15
04
2019
pubmed:
6
5
2019
medline:
15
9
2020
entrez:
6
5
2019
Statut:
ppublish
Résumé
We report the development and characterization of a novel, injury-free rat model in which nociceptive sensitization after red light is observed in multiple body areas reminiscent of widespread pain in functional pain syndromes. Rats were exposed to red light-emitting diodes (RLED) (LEDs, 660 nm) at an intensity of 50 Lux for 8 hours daily for 5 days resulting in time- and dose-dependent thermal hyperalgesia and mechanical allodynia in both male and female rats. Females showed an earlier onset of mechanical allodynia than males. The pronociceptive effects of RLED were mediated through the visual system. RLED-induced thermal hyperalgesia and mechanical allodynia were reversed with medications commonly used for widespread pain, including gabapentin, tricyclic antidepressants, serotonin/norepinephrine reuptake inhibitors, and nonsteroidal anti-inflammatory drugs. Acetaminophen failed to reverse the RLED induced hypersensitivity. The hyperalgesic effects of RLED were blocked when bicuculline, a gamma-aminobutyric acid-A receptor antagonist, was administered into the rostral ventromedial medulla, suggesting a role for increased descending facilitation in the pain pathway. Key experiments were subjected to a replication study with randomization, investigator blinding, inclusion of all data, and high levels of statistical rigor. RLED-induced thermal hyperalgesia and mechanical allodynia without injury offers a novel injury-free rodent model useful for the study of functional pain syndromes with widespread pain. RLED exposure also emphasizes the different biological effects of different colors of light exposure. PERSPECTIVE: This study demonstrates the effect of light exposure on nociceptive thresholds. These biological effects of red LED add evidence to the emerging understanding of the biological effects of light of different colors in animals and humans. Understanding the underlying biology of red light-induced widespread pain may offer insights into functional pain states.
Identifiants
pubmed: 31054915
pii: S1526-5900(18)30814-9
doi: 10.1016/j.jpain.2019.04.008
pmc: PMC6824986
mid: NIHMS1528412
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1293-1306Subventions
Organisme : NINDS NIH HHS
ID : K08 NS104272
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT009716
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042852
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS098772
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 the American Pain Society. Published by Elsevier Inc. All rights reserved.
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