Benzophenone-2 Concentration and Its Effect on Oxidative Stress and Apoptosis Markers in Rat Brain.
Benzophenone-2
Brain concentration
Oxidative stress
UV filters
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
07
11
2018
accepted:
29
01
2019
revised:
24
01
2019
pubmed:
23
4
2019
medline:
10
1
2020
entrez:
23
4
2019
Statut:
ppublish
Résumé
Benzophenones, frequently used as UV chemical filters, are absorbed through the skin and can exert systemic adverse effects. So far, most of the data are related to their action on sex hormone receptors whereas potential neurotoxic effect is expected mainly on the basis of in vitro studies. The aim of the present study was to determine concentrations of BP-2, oxidative stress and apoptosis markers in the rat brain after topical administration of this compound. Male Wistar rats were treated dermally with BP-2 (100 mg/kg, 4 weeks), and next, blood and tissue BP-2 concentrations and oxidative stress and apoptotic markers in the frontal cortex and hippocampus were determined. After dermal BP-2 administration, blood level of this compound was about 300 ng/ml while in the liver and adipose tissue 1354 and 823 ng/g wt tissue, respectively. In the studied brain structures, the levels of the test compound were from 5 to 19 ng/g tissue. In the hippocampus, where BP-2 level was about 3.5-fold lower than in the frontal cortex, no significant changes in either oxidative stress and apoptosis markers were observed. There was also no change in apoptosis markers in the frontal cortex but unexpectedly the oxidative stress markers were reduced. The research showed that BP-2 passes through the blood-brain barrier but its concentration in the brain structures are much lower than in the blood. This compound did not exacerbate oxidative stress and apoptosis markers in the hippocampus and frontal cortex, and even lowered oxidative stress in the frontal cortex.
Identifiants
pubmed: 31006828
doi: 10.1007/s12640-019-0011-y
pii: 10.1007/s12640-019-0011-y
pmc: PMC6570683
doi:
Substances chimiques
Benzophenones
0
2,2',4,4'-tetrahydroxybenzophenone
PRR8K3H9VN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-48Références
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