The Effect of Gonadotropin-Releasing Hormone Analogue on Final Adult Height in Children with Idiopathic Short Stature.
Final adult height
Gonadotropin-releasing hormone analogues
Short stature
Journal
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
ISSN: 1423-0151
Titre abrégé: Med Princ Pract
Pays: Switzerland
ID NLM: 8901334
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
07
2018
accepted:
27
03
2019
pubmed:
18
4
2019
medline:
13
6
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
To assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa). All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2 and 3, who achieved their FAH between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH, and mid-parental height of 28 children with ISS who received GnRHa treatment for 1.8 ± 1.0 years to delay their puberty were compared to 31 untreated children. The FAHs of the treated and the untreated girls were 151.3 ± 5.1 and 146.8 ± 3.8 cm (p = 0.01), respectively. The FAHs of the treated and the untreated boys were 156.4 ± 4.7 and 152.3 ± 5.7 cm (p = 0.111), respectively. The height gain in the treated and the untreated girls was 1.6 ± 7.8 and -3.6 ± 5.7 cm (p = 0.036), respectively. Height gain in the treated and the untreated boys was -5.1 ± 13.6 and -11.5 ± 8.4 cm (p = 0.171), respectively. GnRHa therapy has a modest effect in improving FAH in adolescent females with ISS but not in boys.
Identifiants
pubmed: 30995651
pii: 000499929
doi: 10.1159/000499929
pmc: PMC6944933
doi:
Substances chimiques
Gonadotropin-Releasing Hormone
33515-09-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-516Informations de copyright
© 2019 The Author(s) Published by S. Karger AG, Basel.
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