Gamma tACS over the temporal lobe increases the occurrence of Eureka! moments.

Adult Alpha Rhythm Female Gamma Rhythm Humans Male Problem Solving Temporal Lobe / physiology Transcranial Direct Current Stimulation / methods

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
08 04 2019
Historique:
received: 24 10 2018
accepted: 22 03 2019
entrez: 10 4 2019
pubmed: 10 4 2019
medline: 7 10 2020
Statut: epublish

Résumé

The solution to a problem might manifest itself as a burst of unexpected, unpredictable clarity. Such Eureka! events, or Insight moments, are among the most fascinating mysteries of human cognition, whose neurophysiological substrate seems to include a role for oscillatory activity within the α and γ bands in the right parietal and temporal brain regions. We tested this hypothesis on thirty-one healthy participants using transcranial Alternating Current Stimulation (tACS) to externally amplify α (10 Hz) and γ (40 Hz) activity in the right parietal and temporal lobes, respectively. During γ-tACS over the right temporal lobe, we observed an increase in accuracy on a verbal insight task. Furthermore, electroencephalography (EEG) data revealed an increase in γ spectral power over bilateral temporal lobes after stimulation. Additionally, resting-state functional MRI data acquired before the stimulation session suggested a correlation between behavioral response to right temporal lobe tACS and functional connectivity of bilateral temporal lobes, in line with the bilateral increase in γ band revealed by EEG. Overall, results suggest the possibility of enhancing the probability of generating Eureka! moments in humans by means of frequency-specific noninvasive brain stimulation.

Identifiants

DOI: 10.1038/s41598-019-42192-z PMID: 30962465 PMC: PMC6453961
pubmed: 30962465
doi: 10.1038/s41598-019-42192-z
pii: 10.1038/s41598-019-42192-z
pmc: PMC6453961
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5778

Subventions

Organisme : NICHD NIH HHS
ID : K01 HD091283
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD069776
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073601
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH099196
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS082870
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS085491
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States

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Auteurs

Emiliano Santarnecchi (E)

Berenson-Allen Center for Non-Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. esantarn@bidmc.harvard.edu.
Brain Investigation & Neuromodulation Laboratory (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Siena, Italy. esantarn@bidmc.harvard.edu.

Giulia Sprugnoli (G)

Brain Investigation & Neuromodulation Laboratory (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Siena, Italy.

Emanuela Bricolo (E)

Psychology Department, University of Milano-Bicocca, Milan, Italy.
Milan Center for Neuroscience, Milan, Italy.
ORCID: 0000-0002-8725-0306

Giulio Costantini (G)

Psychology Department, University of Milano-Bicocca, Milan, Italy.
ORCID: 0000-0001-6610-5452

Sook-Lei Liew (SL)

Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.

Christian S Musaeus (CS)

Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-6442-2910

Carola Salvi (C)

Northwestern University, Psychology department, Evanston, IL, USA.
Rehabilitation Institute of Chicago, Chicago, IL, USA.

Alvaro Pascual-Leone (A)

Berenson-Allen Center for Non-Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Alessandro Rossi (A)

Brain Investigation & Neuromodulation Laboratory (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Siena, Italy.
Human Physiology Section, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Simone Rossi (S)

Brain Investigation & Neuromodulation Laboratory (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Siena, Italy.
Human Physiology Section, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

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Classifications MeSH

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Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Ondes du cerveau › Rythme gamma › Gamma tACS over the temporal lobe increases...
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