False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.
Adult
Aged
Antibody Specificity
Autoantibodies
/ blood
Autoantigens
/ immunology
Diagnostic Errors
Epitopes
/ immunology
False Positive Reactions
Female
Guillain-Barre Syndrome
/ blood
Humans
Male
Middle Aged
Myasthenia Gravis
/ blood
Prospective Studies
Radioimmunoprecipitation Assay
Receptors, Nicotinic
/ immunology
Symptom Assessment
Young Adult
Acetylcholine receptor
Antibodies
False positive
Myasthenia gravis
Radioimmunoprecipitation assay
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
14
03
2019
revised:
01
04
2019
accepted:
01
04
2019
pubmed:
9
4
2019
medline:
31
3
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two patients had transiently raised AChR antibodies associated with Guillain-Barré syndrome. Antibodies to clustered AChRs, in a live cell-based assay, were negative in all five patients, suggesting that results from the RIAs were false-positives. It is possible that the AChR antibodies detected by RIA in these cases were non-pathogenic, and directed to intracellular epitopes of the AChR.
Identifiants
pubmed: 30959340
pii: S0165-5728(19)30119-5
doi: 10.1016/j.jneuroim.2019.04.001
pii:
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Epitopes
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-72Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.