Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review.
Aged
Anastomosis, Surgical
/ adverse effects
Anastomotic Leak
/ diagnosis
Carcinoma
/ pathology
Esophageal Neoplasms
/ pathology
Esophagectomy
/ adverse effects
Esophagogastric Junction
/ pathology
Female
Gastrectomy
/ adverse effects
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Risk Assessment
Risk Factors
Stomach Neoplasms
/ pathology
Time Factors
Treatment Outcome
Gastroesophageal junction carcinoma
anastomotic leakage
disease-free survival
esophageal carcinoma
recurrence
review
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
26
02
2019
revised:
18
03
2019
accepted:
20
03
2019
entrez:
7
4
2019
pubmed:
7
4
2019
medline:
24
4
2019
Statut:
ppublish
Résumé
Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients. The frequency of anastomotic leakage ranged from 7.2 to 11.2%. Patients affected by anastomotic leakage had a recurrence rate of 9-56%. Closer follow-up or even more aggressive oncological therapy should be considered for patients affected by anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction.
Sections du résumé
BACKGROUND
BACKGROUND
Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease.
MATERIALS AND METHODS
METHODS
A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients.
RESULTS
RESULTS
The frequency of anastomotic leakage ranged from 7.2 to 11.2%. Patients affected by anastomotic leakage had a recurrence rate of 9-56%.
CONCLUSION
CONCLUSIONS
Closer follow-up or even more aggressive oncological therapy should be considered for patients affected by anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction.
Identifiants
pubmed: 30952703
pii: 39/4/1651
doi: 10.21873/anticanres.13270
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1651-1660Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.