Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases.
Adjuvants, Immunologic
Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune Diseases
/ epidemiology
Child
Child, Preschool
Connective Tissue Diseases
/ epidemiology
Female
Giant Cell Arteritis
/ epidemiology
Hepatitis B Vaccines
/ immunology
Humans
Infant
Infant, Newborn
Inflammation
/ epidemiology
Influenza Vaccines
/ immunology
Israel
/ epidemiology
Male
Middle Aged
Syndrome
Vaccination
/ statistics & numerical data
Young Adult
ASIA syndrome
Foreign material
International syndrome registry
Silicone breast implants
Vaccines
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
03
2019
revised:
18
03
2019
accepted:
24
03
2019
pubmed:
30
3
2019
medline:
3
4
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001). Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Sections du résumé
BACKGROUND
We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.
METHODS
Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.
RESULTS
The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).
CONCLUSIONS
Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Identifiants
pubmed: 30922961
pii: S1521-6616(19)30130-5
doi: 10.1016/j.clim.2019.03.007
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Hepatitis B Vaccines
0
Influenza Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.