Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth.
Animals
Cell Line
Cell Line, Tumor
Cell Proliferation
/ physiology
Extracellular Matrix
/ pathology
Humans
Melanoma
/ pathology
Mice
Mice, Inbred C57BL
Nerve Regeneration
/ physiology
Schwann Cells
/ pathology
Signal Transduction
/ physiology
Tumor Microenvironment
/ physiology
Wound Healing
/ physiology
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
09
12
2018
revised:
29
01
2019
accepted:
20
03
2019
pubmed:
28
3
2019
medline:
8
2
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
The tumor microenvironment has been compared with a nonhealing wound involving a complex interaction between multiple cell types. Schwann cells, the key regulators of peripheral nerve repair, have recently been shown to directly affect nonneural wound healing. Their role in cancer progression, however, has been largely limited to neuropathic pain and perineural invasion. In this study, we showed that melanoma activated otherwise dormant functions of Schwann cells aimed at nerve regeneration and wound healing. Such reprogramming of Schwann cells into repair-like cells occurred during the destruction and displacement of neurons as the tumor expanded and via direct signaling from melanoma cells to Schwann cells, resulting in activation of the nerve injury response. Melanoma-activated Schwann cells significantly altered the microenvironment through their modulation of the immune system and the extracellular matrix in a way that promoted melanoma growth
Identifiants
pubmed: 30914431
pii: 0008-5472.CAN-18-3872
doi: 10.1158/0008-5472.CAN-18-3872
pmc: PMC6522315
mid: NIHMS1525621
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2736-2747Subventions
Organisme : NCI NIH HHS
ID : R01 CA196286
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA121973
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA191522
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL114453
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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