STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.
Animals
Autophagy
/ drug effects
Autophagy-Related Proteins
/ antagonists & inhibitors
Biomarkers
Cell Line
Diabetes Mellitus, Experimental
/ metabolism
Diabetic Neuropathies
/ metabolism
Gene Knockdown Techniques
Glucose
/ pharmacology
Histone Deacetylase 1
/ antagonists & inhibitors
Histone Deacetylases
/ genetics
Hydroxamic Acids
/ pharmacology
Mice
Microtubule-Associated Proteins
/ biosynthesis
Myelin Sheath
/ pathology
Nerve Fibers, Myelinated
/ pathology
Peptide Synthases
/ antagonists & inhibitors
Phosphorylation
Protein Processing, Post-Translational
RNA Interference
RNA, Small Interfering
/ genetics
Rats
STAT3 Transcription Factor
/ metabolism
Schwann Cells
/ drug effects
Sciatic Nerve
/ metabolism
Tyrphostins
/ pharmacology
Up-Regulation
Atg3
JAK-STAT3 signaling
LC3
P62
histone deacetylase 1
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
27
3
2019
medline:
27
5
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
Schwann cells are the main supportive cells of the peripheral nerves. Schwann cells suffer inhibition of autophagy under hyperglycemia treatment in diabetic peripheral neuropathy (DPN). However, the exact mechanism is still not fully elucidated. We first observed the decrease of autophagy markers (LC3-II/LC3-I, P62) in the sciatic nerves of diabetic mice
Identifiants
pubmed: 30913399
doi: 10.1096/fj.201900127R
doi:
Substances chimiques
Autophagy-Related Proteins
0
Biomarkers
0
Hydroxamic Acids
0
LC3 protein, rat
0
Map1lc3b protein, mouse
0
Microtubule-Associated Proteins
0
RNA, Small Interfering
0
STAT3 Transcription Factor
0
Stat3 protein, rat
0
Tyrphostins
0
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide
0
trichostatin A
3X2S926L3Z
Hdac1 protein, rat
EC 3.5.1.98
Hdac5 protein, rat
EC 3.5.1.98
Histone Deacetylase 1
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Atg3 protein, rat
EC 6.3.2.-
Peptide Synthases
EC 6.3.2.-
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM