Alteration level of hippocampus BDNF expression and long-term potentiation upon microinjection of BRL15572 hydrochloride in a rat model of methamphetamine relapse.
Animals
Biphenyl Compounds
/ pharmacology
Brain-Derived Neurotrophic Factor
/ genetics
Central Nervous System Stimulants
/ pharmacology
Conditioning, Classical
/ drug effects
Conditioning, Operant
/ drug effects
Extinction, Psychological
/ drug effects
Gene Expression Regulation
/ genetics
Hippocampus
/ metabolism
Long-Term Potentiation
/ drug effects
Male
Methamphetamine
/ metabolism
Microinjections
Neuronal Plasticity
/ drug effects
Piperazines
/ pharmacology
Rats
Receptors, Serotonin
/ metabolism
Recurrence
Serotonin
/ metabolism
Serotonin 5-HT1 Receptor Antagonists
/ pharmacology
Temporal Lobe
/ metabolism
Brain-derived neurotrophic factor
Hippocampus
Long-term potentiation
Methamphetamine
Serotonin
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
15
11
2018
revised:
08
03
2019
accepted:
15
03
2019
pubmed:
25
3
2019
medline:
18
4
2020
entrez:
25
3
2019
Statut:
ppublish
Résumé
Methamphetamine (METH) relapse affects the function of the serotonergic system, which this system important for synaptic plasticity and brain-derived neurotrophic factor (BDNF) level. While there is a clear distribution of serotonin receptors in the reward and memory areas but the function of 5-HT
Identifiants
pubmed: 30904722
pii: S0361-9230(18)30895-5
doi: 10.1016/j.brainresbull.2019.03.008
pii:
doi:
Substances chimiques
Bdnf protein, rat
0
Biphenyl Compounds
0
Brain-Derived Neurotrophic Factor
0
Central Nervous System Stimulants
0
Piperazines
0
Receptors, Serotonin
0
Serotonin 5-HT1 Receptor Antagonists
0
Serotonin
333DO1RDJY
Methamphetamine
44RAL3456C
BRL 15572
LY8CZE6XUD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-24Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.