Health-related quality of life in glomerular disease.

Adolescent Adult Aged Child Edema / etiology Female Glomerulonephritis / complications Humans Longitudinal Studies Male Middle Aged Quality of Life Self Report / statistics & numerical data
edema health-related quality of life patient-reported outcomes primary glomerular disease

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
05 2019
Historique:
received: 29 03 2018
revised: 30 11 2018
accepted: 06 12 2018
pubmed: 23 3 2019
medline: 3 4 2020
entrez: 23 3 2019
Statut: ppublish

Résumé

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.

Identifiants

DOI: 10.1016/j.kint.2018.12.018 PMID: 30898342 PMC: PMC6743723
pubmed: 30898342
pii: S0085-2538(19)30046-8
doi: 10.1016/j.kint.2018.12.018
pmc: PMC6743723
mid: NIHMS1049257
pii:
doi:

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1209-1224

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK100846
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK100845
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK100867
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK100866
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK100846
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK100876
Pays : United States

Investigateurs

Wooin Ahn (W)
Gerald B Appel (GB)
Revekka Babayev (R)
Ibrahim Batal (I)
Andrew S Bomback (AS)
Eric Brown (E)
Eric S Campenot (ES)
Pietro Canetta (P)
Lucrezia Carlassara (L)
Brenda Chan (B)
Debanjana Chatterjee (D)
Vivette D D'Agati (VD)
Elisa Delbarba (E)
Samriti Dogra (S)
Hilda Fernandez (H)
Bartosz Foroncewicz (B)
Ali G Gharavi (AG)
Gian Marco Ghiggeri (GM)
William H Hines (WH)
S Ali Husain (SA)
Namrata G Jain (NG)
Pascale Khairallah (P)
Byum Hee Kil (BH)
Krzysztof Kiryluk (K)
Anushya Jeyabalan (A)
Wai L Lau (WL)
Fangming Lin (F)
Francesca Lugani (F)
Maddalena Marasa (M)
Glen Markowitz (G)
Sumit Mohan (S)
Xueru Mu (X)
Krzysztof Mucha (K)
Thomas L Nickolas (TL)
Stacy Piva (S)
Jai Radhakrishnan (J)
Maya K Rao (MK)
Regunathan-Shenk Renu (RS)
Simone Sanna-Cherchi (S)
Dominick Santoriello (D)
Shayan Shirazian (S)
Michael B Stokes (MB)
Natalie Uy (N)
Anthony M Valeri (AM)
Larry A Greenbaum (LA)
William E Smoyer (WE)
Amira Al-Uzri (A)
Josephine Ambruzs (J)
Isa Ashoor (I)
Diego Aviles (D)
Rossana Baracco (R)
John Barcia (J)
Sharon Bartosh (S)
Craig Belsha (C)
Corinna Bowers (C)
Michael C Braun (MC)
Yi Cai (Y)
Vladimir Chernitskiy (V)
Aftab Chishti (A)
Donna Claes (D)
Kira Clark (K)
Carl Cramer (C)
Keefe Davis (K)
Elif Erkan (E)
Daniel Feig (D)
Michael Freundlich (M)
Joseph Gaut (J)
Rasheed Gbadegesin (R)
Melisha Hanna (M)
Guillermo Hidalgo (G)
David Hooper (D)
Tracy E Hunley (TE)
Amrish Jain (A)
Mahmoud Kallash (M)
Margo Kamel (M)
Myda Khalid (M)
Jon B Klein (JB)
Theresa Kump (T)
Jerome C Lane (JC)
Helen Liapis (H)
John Mahan (J)
Carla Nester (C)
Cynthia Pan (C)
Larry Patterson (L)
Hiren Patel (H)
Alice Raad (A)
Adelaide Revell (A)
Michelle N Rheault (MN)
Cynthia Silva (C)
Rajasree Sreedharan (R)
Tarak Srivastava (T)
Julia Steinke (J)
Susan Sumner (S)
Katherine Twombley (K)
Scott E Wenderfer (SE)
Tetyana L Vasylyeva (TL)
Chia-Shi Wang (CS)
Donald J Weaver (DJ)
Craig S Wong (CS)
Hong Yin (H)
Anand Achanti (A)
Salem Almaani (S)
Isabelle Ayoub (I)
Milos Budisavljevic (M)
Maggie D'Angelo (M)
Huma Fatima (H)
Ronald Falk (R)
Agnes Fogo (A)
Keisha Gibson (K)
Dorey Glenn (D)
Susan Hogan (S)
J Charles Jennette (JC)
Bruce Julian (B)
Jason Kidd (J)
Louis-Philippe Laurin (LP)
H Davis Massey (HD)
Amy Mottl (A)
Shannon Murphy (S)
Patrick Nachman (P)
Tibor Nadasdy (T)
Jan Novak (J)
Samir Parikh (S)
Caroline Poulton (C)
Thomas Brian Powell (TB)
Bryce Reeve (B)
Matthew Renfrow (M)
Monica Reynolds (M)
Dana Rizk (D)
Brad Rovin (B)
Virginie Royal (V)
Neil Sanghani (N)
Sally Self (S)
Sharon Adler (S)
Nada Alachkar (N)
Charles Alpers (C)
Raed Bou Matar (RB)
Carmen Avila-Casado (C)
Serena Bagnasco (S)
Emily Brede (E)
Elizabeth Brown (E)
Daniel Cattran (D)
Michael Choi (M)
Katherine M Dell (KM)
Darren Dewalt (D)
Michelle Denburg (M)
Ram Dukkipati (R)
Fernando C Fervenza (FC)
Alessia Fornoni (A)
Crystal Gadegbeku (C)
Patrick Gipson (P)
Anny Gonzalez-Zea (A)
Leah Hasely (L)
Elizabeth Hendren (E)
Sangeeta Hingorani (S)
Michelle Hladunewich (M)
Jonathan Hogan (J)
Lawrence B Holzman (LB)
Jean Hou (J)
J Ashley Jefferson (JA)
Kenar Jhaveri (K)
Duncan B Johnstone (DB)
Frederick Kaskel (F)
Amy Kogan (A)
Jeffrey Kopp (J)
Richard Lafayette (R)
Kevin V Lemley (KV)
Laura Malaga-Dieguez (L)
Kevin Meyers (K)
Alicia Neu (A)
Michelle Marie O'Shaughnessy (MM)
John F O'Toole (JF)
Andrea Oliverio (A)
Matthew Palmer (M)
Rulan Parekh (R)
Renee Pitter (R)
Heather Reich (H)
Kimberly Reidy (K)
Helbert Rondon (H)
Kamalanathan K Sambandam (KK)
Matthew Sampson (M)
John R Sedor (JR)
David T Selewski (DT)
Christine B Sethna (CB)
Jeffrey Schelling (J)
John C Sperati (JC)
Agnes Swiatecka-Urban (A)
Howard Trachtman (H)
Katherine R Tuttle (KR)
Meryl Waldman (M)
Joseph Weisstuch (J)
Roger Wiggins (R)
David Williams (D)
Cheryl Winkler (C)
Suzanne Vento (S)
Eric Young (E)
Olga Zhdanova (O)
Laura Barisoni (L)
Charlotte Beil (C)
Richard Eikstadt (R)
Brenda Gillespie (B)
Debbie S Gipson (DS)
John Graff (J)
Stephen Hewitt (S)
Peg Hill-Callahan (P)
Margaret Helmuth (M)
Emily Herreshoff (E)
Matthias Kretzler (M)
Chrysta Lienczewski (C)
Sarah Mansfield (S)
Laura Mariani (L)
Keith McCullough (K)
Nicholas Moore (N)
Cynthia C Nast (CC)
Bruce M Robinson (BM)
Melissa Sexton (M)
Jonathan Troost (J)
Matthew Wladkowski (M)
Jarcy Zee (J)
Dawn Zinsser (D)
Lisa M Guay-Woodford (LM)

Informations de copyright

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Pietro A Canetta (PA)

Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA. Electronic address: pac2004@cumc.columbia.edu.

Jonathan P Troost (JP)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Shannon Mahoney (S)

Department of Medicine, Division of Renal Diseases and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Amy J Kogon (AJ)

Division of Nephrology, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, USA.

Noelle Carlozzi (N)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Sharon M Bartosh (SM)

Division of Pediatric Nephrology, University of Wisconsin, Madison, Wisconsin, USA.

Yi Cai (Y)

Division of Pediatric Nephrology, Helen DeVos Children's Hospital, Grand Rapids, Michigan, USA.

T Keefe Davis (TK)

Division of Pediatric Nephrology, Washington University School of Medicine, St Louis, Missouri, USA.

Hilda Fernandez (H)

Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Alessia Fornoni (A)

Department of Medicine, University of Miami, Miami, Florida, USA.

Rasheed A Gbadegesin (RA)

Department of Pediatrics, Duke University, Durham, North Carolina, USA.

Emily Herreshoff (E)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

John D Mahan (JD)

Department of Nephrology, Nationwide Children's Hospital, Columbus, Ohio, USA.

Patrick H Nachman (PH)

Department of Medicine, Division of Renal Diseases and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

David T Selewski (DT)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Christine B Sethna (CB)

Division of Pediatric Nephrology, Cohen Children's Medical Center, New Hyde Park, New York, USA.

Tarak Srivastava (T)

Department of Pediatrics, Division of Nephrology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.

Katherine R Tuttle (KR)

Division of Nephrology, University of Washington School of Medicine, Spokane, Washington, USA.

Chia-Shi Wang (CS)

Division of Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.

Ronald J Falk (RJ)

Division of Nephrology and Hypertension, Kidney Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

Ali G Gharavi (AG)

Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Brenda W Gillespie (BW)

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Larry A Greenbaum (LA)

Division of Nephrology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Lawrence B Holzman (LB)

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Matthias Kretzler (M)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Bruce M Robinson (BM)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA; Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.

William E Smoyer (WE)

Department of Nephrology, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatric Nephrology, Ohio State University, Columbus, Ohio, USA.

Lisa M Guay-Woodford (LM)

Deparment of Nephrology, Center for Translational Science, Children's National Health System, Washington, District of Columbia, USA.

Bryce Reeve (B)

Department of Pediatrics, Duke University, Durham, North Carolina, USA.

Debbie S Gipson (DS)

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adolescent › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Sujet âgé › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Health-related quality of life in glomerular disease.
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Oedème › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glomérulonéphrite › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Health-related quality of life in glomerular disease.
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Autorapport › Health-related quality of life in glomerular disease.