Choreographing Immunity in the Skin Epithelial Barrier.
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
19 03 2019
19 03 2019
Historique:
received:
15
01
2019
revised:
25
02
2019
accepted:
27
02
2019
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
21
8
2019
Statut:
ppublish
Résumé
The skin interfaces with the external environment and is home to a myriad of immune cells that patrol the barrier to ward off harmful agents and aid in tissue repair. The formation of the cutaneous immune arsenal begins before birth and evolves throughout our lifetime, incorporating exogenous cues from microbes and inflammatory encounters, to achieve optimal fitness and function. Here, we discuss the context-specific signals that drive productive immune responses in the skin epithelium, highlighting key modulators of these reactions, including hair follicles, neurons, and commensal microbes. We thus also discuss the causal and mechanistic underpinning of inflammatory skin diseases that have been revealed in recent years. Finally, we discuss the non-canonical functions of cutaneous immune cells including their burgeoning role in epithelial regeneration and repair. The rapidly growing field of cutaneous immunity is revealing immune mechanisms and functions that can be harnessed to boost skin health and treat disease.
Identifiants
pubmed: 30893586
pii: S1074-7613(19)30090-1
doi: 10.1016/j.immuni.2019.02.023
pmc: PMC6455972
mid: NIHMS1523122
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
552-565Subventions
Organisme : NIAID NIH HHS
ID : K22 AI135099
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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