[Diagnostic and treatment pitfalls and guidelines for variants of squamous cell carcinomas of the head and neck: on behalf of the REFCOR].
Variants des carcinomes épidermoïdes dans les voies aérodigestives supérieures (VADS), implications pour le diagnostic et la prise en charge, selon les référentiels du REFCOR.
Acantholytic
Acantholytique/adénoïde
Adenoid carcinoma
Adenosquamous
Adénosquameux
Basaloid
Basaloïde
Cancer/carcinome
HNSCC
Head and neck cancer
Lymphoepithelial
Lymphoépithélial
Papillaire
Papillary
Sarcomatoid
Spindle cell
Squamous cell carcinoma
Variant
Verrucous
Verruqueux
Voies aérodigestives supérieures
À cellules fusiformes/sarcomatoïde
Épidermoïde
Journal
Bulletin du cancer
ISSN: 1769-6917
Titre abrégé: Bull Cancer
Pays: France
ID NLM: 0072416
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
07
12
2018
accepted:
19
01
2019
pubmed:
18
3
2019
medline:
19
4
2019
entrez:
18
3
2019
Statut:
ppublish
Résumé
Among the 20,000 new cases of head and neck neoplasms in France each year, squamous cell carcinomas (HNSCC) represent about 90 % of the cases. Among these, variants of conventional squamous cell carcinomas represent between 5% and 10% of cases. Patient history and risk factors are often similar from those of conventional HSNCC. Variants may, however, be misdiagnosed, which can lead to therapeutic mismanagement due to confusion with sarcomas, glandular tumors or even benign tumors. Diagnostic workup needs to be more cautionary or to include additional exams not to omit their most aggressive component in the case of composite tumors or to under stage the tumor. Immunohistochemistry and specific molecular analyses may be required for proper diagnosis. Central pathological review may also be essential for some of these variants. In addition, some variants are radioresistant and, conversely, others are radiosensitive. An update of the REFCOR 2008 standards was carried out in the light of the international literature and the 2017 WHO/IARC classification for the seven main variants of HNSCC, verrucous, acantholytic (to be named adenoid carcinomas), basaloid, papillary, spindle cell (incorrectly named sarcomatoid), adenosquamous and lymphoepithelial carcinomas.
Identifiants
pubmed: 30878134
pii: S0007-4551(19)30113-4
doi: 10.1016/j.bulcan.2019.01.015
pii:
doi:
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
395-403Informations de copyright
Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.