Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training.
Adult
Aging
/ metabolism
Blood Glucose
/ metabolism
Ceramides
/ metabolism
Diglycerides
/ metabolism
Exercise
/ physiology
Fatty Acids
/ metabolism
Female
Glucose
/ metabolism
High-Intensity Interval Training
/ methods
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Lipid Metabolism
/ physiology
Lipids
/ physiology
Male
Middle Aged
Muscle, Skeletal
/ metabolism
Obesity
/ metabolism
Overweight
/ metabolism
aging
ceramide
diacylglycerol
high-intensity interval training
insulin resistance
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Mar 2019
12 Mar 2019
Historique:
received:
29
12
2018
revised:
06
03
2019
accepted:
07
03
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of age and high-intensity interval training (HIIT) on ceramide and diacylglycerol content in muscle. Fourteen young (33 ± 1) and 22 older (63 ± 1) overweight to obese subjects performed 6 weeks HIIT three times a week. Maximal oxygen uptake and body composition were measured and muscle biopsies and fasting blood samples were obtained. Muscle ceramide and diacylglycerol were measured by gas-liquid chromatography and proteins in insulin signaling, lipid and glucose metabolism were measured by Western blotting. Content of ceramide and diacylglycerol total, saturated, C16:0 and C18:0 fatty acids and C18:1 ceramide were higher in older compared to young. HIIT reduced saturated and C18:0 ceramides, while the content of the proteins involved in glucose (GLUT4, glycogen synthase, hexokinase II, AKT) and lipid metabolism (adipose triglyceride lipase, fatty acid binding protein) were increased after HIIT. We demonstrate a higher content of saturated ceramide and diacylglycerol fatty acids in the muscle of older subjects compared to young. Moreover, the content of saturated ceramides was reduced and muscle glucose metabolism improved at protein level after HIIT. This study highlights an increased content of saturated ceramides in aging which could be speculated to influence insulin sensitivity.
Identifiants
pubmed: 30871020
pii: ijms20051240
doi: 10.3390/ijms20051240
pmc: PMC6429484
pii:
doi:
Substances chimiques
1,2-diacylglycerol
0
Blood Glucose
0
Ceramides
0
Diglycerides
0
Fatty Acids
0
Insulin
0
Lipids
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Danish Diabetes Academy
ID : No grant number available
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