Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.
Actin Cytoskeleton
/ chemistry
Actins
/ genetics
Animals
CRISPR-Cas Systems
Carrier Proteins
/ genetics
Cell Movement
/ genetics
Cell Polarity
/ genetics
Contractile Proteins
/ chemistry
Dictyostelium
/ genetics
Disease Models, Animal
Formins
Humans
Melanoma, Experimental
/ genetics
Mice
Microscopy, Electron
Muscle Contraction
/ genetics
rhoA GTP-Binding Protein
/ chemistry
RhoGTPase
actin cortex
cell migration
cytokinesis
formin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
entrez:
28
2
2019
pubmed:
28
2
2019
medline:
3
5
2019
Statut:
ppublish
Résumé
The contractile actin cortex is a thin layer of filamentous actin, myosin motors, and regulatory proteins beneath the plasma membrane crucial to cytokinesis, morphogenesis, and cell migration. However, the factors regulating actin assembly in this compartment are not well understood. Using the
Identifiants
pubmed: 30808751
pii: 1821638116
doi: 10.1073/pnas.1821638116
pmc: PMC6397521
doi:
Substances chimiques
Actins
0
Carrier Proteins
0
Contractile Proteins
0
Diap1 protein, mouse
0
Formins
0
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3594-3603Subventions
Organisme : Wellcome Trust
ID : 094231/Z/10/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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