Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand.
Animals
Antineoplastic Agents
/ chemical synthesis
Catechols
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Coordination Complexes
/ chemical synthesis
DNA
/ drug effects
Drug Screening Assays, Antitumor
G2 Phase Cell Cycle Checkpoints
/ drug effects
Humans
Indoles
/ chemical synthesis
Ligands
Male
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Reactive Oxygen Species
/ metabolism
Salmon
Vanadium
/ chemistry
Anticancer drugs
DNA binding
Diindolylmethane
Reactive oxygen species
Vanadium
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
14
01
2019
revised:
05
02
2019
accepted:
08
02
2019
pubmed:
21
2
2019
medline:
7
5
2020
entrez:
21
2
2019
Statut:
ppublish
Résumé
In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.
Identifiants
pubmed: 30784705
pii: S0162-0134(19)30027-3
doi: 10.1016/j.jinorgbio.2019.02.005
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Catechols
0
Coordination Complexes
0
Indoles
0
Ligands
0
Reactive Oxygen Species
0
Vanadium
00J9J9XKDE
DNA
9007-49-2
3,3'-diindolylmethane
SSZ9HQT61Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.