Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort.
Adolescent
Adult
Age Factors
Azoospermia
/ diagnosis
Cohort Studies
Cross-Sectional Studies
Fertility Preservation
/ methods
Humans
Incidence
Internationality
Male
Retrospective Studies
Risk Assessment
Semen Analysis
/ methods
Sperm Count
Sperm Motility
Tertiary Care Centers
United Kingdom
United States
Varicocele
/ diagnosis
Young Adult
Journal
Urology
ISSN: 1527-9995
Titre abrégé: Urology
Pays: United States
ID NLM: 0366151
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
18
11
2018
revised:
24
01
2019
accepted:
28
01
2019
pubmed:
17
2
2019
medline:
27
6
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5years (interquartile range [IQR] 15.2-17.6) and 30.8years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30million/mL (IQR 10-57) vs 39million/mL (IQR 14-57), P = .2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P = .01. Median total motile sperm count was 11million (IQR 1.4-33) for adolescents vs 29million (IQR 13-69) for adults, P <.001. Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.
Identifiants
pubmed: 30771377
pii: S0090-4295(19)30134-7
doi: 10.1016/j.urology.2019.01.027
pmc: PMC6475495
mid: NIHMS1521528
pii:
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-123Subventions
Organisme : NIDDK NIH HHS
ID : K12 DK083014
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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