PDK1 Mediates
Animals
Apoptosis
/ genetics
CRISPR-Cas Systems
Cell Line, Tumor
Cell Proliferation
/ drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Gene Editing
Gene Expression
Gene Knockdown Techniques
Humans
Loss of Function Mutation
Mice
Phosphatidylinositol 3-Kinases
/ metabolism
Protein Kinase Inhibitors
/ pharmacology
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
/ metabolism
Receptor, Notch1
/ genetics
Signal Transduction
/ drug effects
Squamous Cell Carcinoma of Head and Neck
/ drug therapy
TOR Serine-Threonine Kinases
/ metabolism
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
16
10
2018
revised:
20
12
2018
accepted:
11
02
2019
pubmed:
17
2
2019
medline:
7
7
2020
entrez:
17
2
2019
Statut:
ppublish
Résumé
Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including PI3K/mTOR inhibition caused apoptosis and decreased colony numbers in HNSCC cell lines harboring Our findings suggest that
Identifiants
pubmed: 30770351
pii: 1078-0432.CCR-18-3276
doi: 10.1158/1078-0432.CCR-18-3276
pmc: PMC6548600
mid: NIHMS1522078
doi:
Substances chimiques
NOTCH1 protein, human
0
PDK1 protein, human
0
Protein Kinase Inhibitors
0
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
0
Receptor, Notch1
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3329-3340Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024179
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221675
Pays : United States
Organisme : NIDCR NIH HHS
ID : U01 DE025181
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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