Chronic hepatitis B viral infection among RA patients-a cross-sectional control study.
Autoimmune disease
Autoimmunity
Hepatitis B virus
Rheumatoid arthritis
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
17
01
2019
accepted:
21
01
2019
pubmed:
9
2
2019
medline:
4
12
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. We aimed to assess the association between RA and chronic hepatitis B viral infection (HBV). Patients with RA were compared with age- and sex-matched controls regarding the proportion of chronic HBV infection in a case-control study. The chi-square and t tests were used for univariate analysis, whereas a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. There was a significantly higher proportion of chronic HBV infection in RA patients compared with controls (1.19% vs 0.63%, respectively; p < 0.001). In a multivariate logistic regression analysis, RA was significantly associated with chronic HBV infection (OR = 1.89, 95%CI 1.55-2.29, p < 0.001). Patients with RA have a greater proportion of chronic HBV infection than matched controls. Screening for HBV infection among RA patients may be warranted.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. We aimed to assess the association between RA and chronic hepatitis B viral infection (HBV).
METHODS
METHODS
Patients with RA were compared with age- and sex-matched controls regarding the proportion of chronic HBV infection in a case-control study. The chi-square and t tests were used for univariate analysis, whereas a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services.
RESULTS
RESULTS
There was a significantly higher proportion of chronic HBV infection in RA patients compared with controls (1.19% vs 0.63%, respectively; p < 0.001). In a multivariate logistic regression analysis, RA was significantly associated with chronic HBV infection (OR = 1.89, 95%CI 1.55-2.29, p < 0.001).
CONCLUSIONS
CONCLUSIONS
Patients with RA have a greater proportion of chronic HBV infection than matched controls. Screening for HBV infection among RA patients may be warranted.
Identifiants
pubmed: 30734214
doi: 10.1007/s10067-019-04448-x
pii: 10.1007/s10067-019-04448-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1237-1241Références
McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365(23):2205–2219. https://doi.org/10.1056/NEJMra1004965
doi: 10.1056/NEJMra1004965
pubmed: 22150039
Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423(6937):356–361. https://doi.org/10.1038/nature01661
doi: 10.1038/nature01661
Turesson C, O'Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62(8):722–727
doi: 10.1136/ard.62.8.722
pubmed: 12860726
pmcid: 1754626
Myasoedova E, Crowson CS, Turesson C, Gabriel SE, Matteson EL (2011) Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995–2007 versus 1985–1994: a population-based study. J Rheumatol 38(6):983–989
doi: 10.3899/jrheum.101133
pubmed: 21459933
pmcid: 3193155
Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, Williams CA, Spitz PW, Haga M, Kleinheksel SM, Cathey MA (1994) The mortality of rheumatoid arthritis. Arthritis Rheum 37(4):481–494
doi: 10.1002/art.1780370408
pubmed: 8147925
Solomon DH, Karlson EW, Rimm EB, Cannuscio CC, Mandl LA, Manson JE, Stampfer MJ, Curhan GC (2003) Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 107(9):1303–1307
doi: 10.1161/01.CIR.0000054612.26458.B2
pubmed: 12628952
Guler-Yuksel M, Allaart CF, Goekoop-Ruiterman YP, de Vries-Bouwstra JK, van Groenendael JH, Mallee C, de Bois MH, Breedveld FC, Dijkmans BA, Lems WF (2009) Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis. Ann Rheum Dis 68(3):330–336. https://doi.org/10.1136/ard.2007.086348
doi: 10.1136/ard.2007.086348
pubmed: 18375540
Choy E, Sattar N (2009) Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. Ann Rheum Dis 68(4):460–469. https://doi.org/10.1136/ard.2008.101964
doi: 10.1136/ard.2008.101964
pubmed: 19286905
Smitten AL, Simon TA, Hochberg MC, Suissa S (2008) A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res Ther 10(2):R45. https://doi.org/10.1186/ar2404
doi: 10.1186/ar2404
pubmed: 18433475
pmcid: 2453765
van Boekel MA, Vossenaar ER, van den Hoogen FH, van Venrooij WJ (2002) Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 4(2):87–93. https://doi.org/10.1186/ar395
doi: 10.1186/ar395
pubmed: 11879544
Doran MF, Crowson CS, Pond GR, O'Fallon WM, Gabriel SE (2002) Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheumatol 46(9):2287–2293
doi: 10.1002/art.10524
Baum J (1971) Infection in rheumatoid arthritis. Arthritis Rheumatol 14(1):135–137
doi: 10.1002/art.1780140119
Gendelman O, Mahroum N, Comaneshter D, Rotman-Pikielny P, Cohen AD, Amital H, Sherf M (2017) Hepatitis B carrier state among SLE patients: case-control study. Immunol Res 65(1):257–261. https://doi.org/10.1007/s12026-016-8834-6
doi: 10.1007/s12026-016-8834-6
pubmed: 27423436
Maya R, Gershwin ME, Shoenfeld Y (2008) Hepatitis B virus (HBV) and autoimmune disease. Clin Rev Allergy Immunol 34(1):85–102
doi: 10.1007/s12016-007-8013-6
pubmed: 18270862
Watad A, Azrielant S, Bragazzi NL, Sharif K, David P, Katz I, Aljadeff G, Quaresma M, Tanay G, Adawi M, Amital H, Shoenfeld Y (2017) Seasonality and autoimmune diseases: the contribution of the four seasons to the mosaic of autoimmunity. J Autoimmun 82:13–30. https://doi.org/10.1016/j.jaut.2017.06.001
doi: 10.1016/j.jaut.2017.06.001
pubmed: 28624334
Mahroum N, Hejly A, Tiosano S, Gendelman O, Comaneshter D, Cohen AD, Amital H (2017) Chronic hepatitis C viral infection among SLE patients: the significance of coexistence. Immunol Res 65(2):477–481. https://doi.org/10.1007/s12026-016-8886-7
doi: 10.1007/s12026-016-8886-7
pubmed: 28111706
Ramos-Casals M, Muñoz S, Medina F, Jara L-J, Rosas J, Calvo-Alen J, Brito-Zerón P, Forns X, Sánchez-Tapias J-M (2009) Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry). J Rheumatol 36(7):1442–1448
doi: 10.3899/jrheum.080874
pubmed: 19369460
De Virgilio A, Greco A, Magliulo G, Gallo A, Ruoppolo G, Conte M, Martellucci S, de Vincentiis M (2016) Polyarteritis nodosa: a contemporary overview. Autoimmun Rev 15(6):564–570
doi: 10.1016/j.autrev.2016.02.015
pubmed: 26884100
Chen YL, Jing J, Mo YQ, Ma JD, Yang LJ, Chen LF, Zhang X, Yan T, Zheng DH, Pessler F, Dai L (2018) Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis. Arthritis Res Ther 20(1):130. https://doi.org/10.1186/s13075-018-1623-y
doi: 10.1186/s13075-018-1623-y
pubmed: 29921328
pmcid: 6009044
Hsu CS, Lang HC, Huang KY, Lin HH, Chen CL (2016) Association of rheumatoid arthritis and hepatitis B infection: a nationwide nested case-control study from 1999 to 2009 in Taiwan. Medicine (Baltimore) 95(18):e3551
doi: 10.1097/MD.0000000000003551
World Health Organization (2017) Global Hepatitis Programme. Global hepatitis report, 2017
Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL, Chatham WW, Paulus HE, Suarez-almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain A, Volkmann ER, Agrawal H, Bae S, Mudano AS, Patkar NM, Saag KG (2012) 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 64(5):625–639
doi: 10.1002/acr.21641
Kanduc D, Shoenfeld Y (2016) From HBV to HPV: designing vaccines for extensive and intensive vaccination campaigns worldwide. Autoimmun Rev 15(11):1054–1061. https://doi.org/10.1016/j.autrev.2016.07.030
doi: 10.1016/j.autrev.2016.07.030
pubmed: 27490205
Watad A, Bragazzi NL, Adawi M, Aljadeff G, Amital H, Comaneshter D, Cohen AD, Amital D (2017) Anxiety disorder among rheumatoid arthritis patients: insights from real-life data. J Affect Disord 213:30–34. https://doi.org/10.1016/j.jad.2017.02.007
doi: 10.1016/j.jad.2017.02.007
pubmed: 28188994
Watad A, Bragazzi NL, Tiosano S, Yavne Y, Comaneshter D, Cohen AD, Amital H (2018) Alzheimer’s disease in systemic sclerosis patients: a nationwide population-based cohort study. J Alzheimers Dis 65(1):117–124
doi: 10.3233/JAD-180516
pubmed: 30040736
Watad A, Tiosano S, Azrielant S, Whitby A, Comaneshter D, Cohen AD, Shoenfeld Y, Amital H (2017) Low levels of calcium or vitamin D - which is more important in systemic lupus erythematosus patients? An extensive data analysis. Clin Exp Rheumatol 35(1):108–112
pubmed: 27608168
Watad A, Tiosano S, Yahav D, Comaneshter D, Shoenfeld Y, Cohen AD, Amital H (2017) Behcet’s disease and familial Mediterranean fever: two sides of the same coin or just an association? A cross-sectional study. Eur J Intern Med 39:75–78. https://doi.org/10.1016/j.ejim.2016.10.011
doi: 10.1016/j.ejim.2016.10.011
pubmed: 27776949
Dvir R, Sautto GA, Mancini N, Racca S, Diotti RA, Clementi M, Memoli M (2017) Autoimmune hepatitis and occult HCV infection: a prospective single-centre clinical study. Autoimmun Rev 16(3):323–325. https://doi.org/10.1016/j.autrev.2017.01.015
doi: 10.1016/j.autrev.2017.01.015
pubmed: 28161557
Tosato G, Steinberg AD, Blaese RM (1981) Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. N Engl J Med 305(21):1238–1243
doi: 10.1056/NEJM198111193052102
pubmed: 6270556
Wilder RL, Crofford LJ (1991) Do infectious agents cause rheumatoid arthritis? Clin Orthop Relat Res (265):36–41
Balandraud N, Roudier J (2018) Epstein-Barr virus and rheumatoid arthritis. Joint Bone Spine 85(2):165–170. https://doi.org/10.1016/j.jbspin.2017.04.011
doi: 10.1016/j.jbspin.2017.04.011
pubmed: 28499895
Listing J, Gerhold K, Zink A (2013) The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment. Rheumatology 52(1):53–61
doi: 10.1093/rheumatology/kes305
pubmed: 23192911
Singh JA, Cameron C, Noorbaloochi S, Cullis T, Tucker M, Christensen R, Ghogomu ET, Coyle D, Clifford T, Tugwell P, Wells GA (2015) Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet 386(9990):258–265. https://doi.org/10.1016/s0140-6736(14)61704-9
doi: 10.1016/S0140-6736(14)61704-9
pubmed: 25975452
pmcid: 4580232
Alpert E, Isselbacher KJ, Schur PH (1971) The pathogenesis of arthritis associated with viral hepatitis: complement-component studies. N Engl J Med 285(4):185–189
doi: 10.1056/NEJM197107222850401
pubmed: 4996611
Dienstag JL (1981) Hepatitis B as an immune complex disease. Semin Liver Dis 1(1):45–57. https://doi.org/10.1055/s-2008-1063929
doi: 10.1055/s-2008-1063929
pubmed: 6126007
Cacoub P, Saadoun D, Bourlière M, Khiri H, Martineau A, Benhamou Y, Varastet M, Pol S, Thibault V, Rotily M (2005) Hepatitis B virus genotypes and extrahepatic manifestations. J Hepatol 43(5):764–770
doi: 10.1016/j.jhep.2005.05.029
pubmed: 16087273
Lin TC, Hashemi N, Kim SC, Yang YK, Yoshida K, Tedeschi S, Desai R, Solomon DH (2018) Practice pattern of hepatitis B testing in rheumatoid arthritis patients: a cross-national comparison between the US and Taiwan. Arthritis Care Res (Hoboken) 70(1):30–38. https://doi.org/10.1002/acr.23241
doi: 10.1002/acr.23241
Urata Y, Uesato R, Tanaka D, Kowatari K, Nitobe T, Nakamura Y, Motomura S (2011) Prevalence of reactivation of hepatitis B virus replication in rheumatoid arthritis patients. Mod Rheumatol 21(1):16–23
doi: 10.3109/s10165-010-0337-z
pubmed: 20668905
Tamori A, Koike T, Goto H, Wakitani S, Tada M, Morikawa H, Enomoto M, Inaba M, Nakatani T, Hino M (2011) Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts. J Gastroenterol 46(4):556–564
doi: 10.1007/s00535-010-0367-5
pubmed: 21246383
Lahiri M, Dixon WG (2015) Risk of infection with biologic antirheumatic therapies in patients with rheumatoid arthritis. Best Pract Res Clin Rheumatol 29(2):290–305
doi: 10.1016/j.berh.2015.05.009
pubmed: 26362745
Jeong H, Baek SY, Kim SW, Eun YH, Kim IY, Kim H, Lee J, Koh E-M, Cha H-S (2017) Comorbidities of rheumatoid arthritis: results from the Korean National Health and Nutrition Examination Survey. PLoS One 12(4):e0176260
doi: 10.1371/journal.pone.0176260
pubmed: 28423031
pmcid: 5397042