Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.
Animals
Bacteria
/ genetics
Colitis
/ chemically induced
Colon
/ metabolism
Dextran Sulfate
Disease Models, Animal
Fatty Acids, Volatile
/ metabolism
Gastrointestinal Microbiome
Inflammation
/ chemically induced
Inflammatory Bowel Diseases
Interleukin-10
/ metabolism
Intestinal Mucosa
/ metabolism
Macrophages
/ metabolism
Male
Mice, Inbred BALB C
Probiotics
/ therapeutic use
Species Specificity
T-Lymphocytes, Regulatory
/ metabolism
Trinitrobenzenesulfonic Acid
animal studies
inflammatory bowel disease
intestinal microbiota
lactic acid
macrophage
probiotics
regulatory T (Treg) cells
short-chain fatty acids (SCFA)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
02 Feb 2019
02 Feb 2019
Historique:
received:
07
12
2018
revised:
21
01
2019
accepted:
23
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
26
2
2019
Statut:
epublish
Résumé
A growing body of evidence suggests that probiotic functionality is not accurately predicted by their taxonomy. Here, we have set up a study to investigate the effectiveness of two probiotic formulations containing a blend of seven bacterial species in modulating intestinal inflammation in two rodent models of colitis, induced by treating mice with 2,4,6-Trinitrobenzenesulfonic acid (TNBS) or dextran sodium sulfate (DSS). Despite the taxonomy of the bacterial species in the two probiotic formulations being similar, only one preparation (Blend 2-Vivomixx) effectively attenuated the development of colitis in both models. In the TNBS model of colitis, Blend 2 reduced the expression of pro-inflammatory genes while increasing the production of anti-inflammatory cytokines, promoting the expansion M2 macrophages and the formation of IL-10-producing Treg cells in the colon's
Identifiants
pubmed: 30717413
pii: nu11020325
doi: 10.3390/nu11020325
pmc: PMC6412585
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Interleukin-10
130068-27-8
Trinitrobenzenesulfonic Acid
8T3HQG2ZC4
Dextran Sulfate
9042-14-2
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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