Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer.
Animals
Cell Degranulation
Cell Line, Tumor
Cell Survival
Chemokine CCL11
/ metabolism
Colorectal Neoplasms
/ immunology
Cytotoxicity, Immunologic
Disease Models, Animal
Eosinophils
/ drug effects
Gene Expression Profiling
Humans
Immunotherapy, Adoptive
Interferon-gamma
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Proteomics
Signal Transduction
Tumor Microenvironment
/ immunology
Journal
Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
23
07
2018
revised:
14
10
2018
accepted:
17
12
2018
pubmed:
23
1
2019
medline:
21
5
2020
entrez:
23
1
2019
Statut:
ppublish
Résumé
Immunotherapies targeting T lymphocytes are revolutionizing cancer therapy but only benefit a subset of patients, especially in colorectal cancer. Thus, additional insight into the tumor microenvironment (TME) is required. Eosinophils are bone marrow-derived cells that have been largely studied in the context of allergic diseases and parasite infections. Although tumor-associated eosinophilia has been described in various solid tumors including colorectal cancer, knowledge is still missing regarding eosinophil activities and even the basic question of whether the TME promotes eosinophil recruitment without additional manipulation (e.g., immunotherapy) is unclear. Herein, we report that eosinophils are recruited into developing tumors during induction of inflammation-induced colorectal cancer and in mice with the
Identifiants
pubmed: 30665890
pii: 2326-6066.CIR-18-0494
doi: 10.1158/2326-6066.CIR-18-0494
doi:
Substances chimiques
Ccl11 protein, mouse
0
Chemokine CCL11
0
IFNG protein, mouse
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-400Informations de copyright
©2019 American Association for Cancer Research.