Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice.
Animals
Corticotropin-Releasing Hormone
/ genetics
Dependovirus
/ genetics
Diet, Western
Echocardiography
Gene Transfer Techniques
Glucose
Heart Failure
/ diagnosis
Homeostasis
Mice
Mice, Transgenic
Myocardium
/ metabolism
Signal Transduction
Transduction, Genetic
Urocortins
/ genetics
Ventricular Function, Left
/ genetics
adeno-associated virus
gene therapy
insulin resistance
type 2 diabetes
Journal
Human gene therapy
ISSN: 1557-7422
Titre abrégé: Hum Gene Ther
Pays: United States
ID NLM: 9008950
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
17
1
2019
medline:
13
3
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated virus 8 encoding urocortin 2 (AAV8.
Identifiants
pubmed: 30648430
doi: 10.1089/hum.2018.150
pmc: PMC6589493
doi:
Substances chimiques
Urocortins
0
urocortin 2, mouse
0
Corticotropin-Releasing Hormone
9015-71-8
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
693-701Subventions
Organisme : BLRD VA
ID : I01 BX001515
Pays : United States
Organisme : BLRD VA
ID : I01 BX003774
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL066941
Pays : United States
Organisme : NHLBI NIH HHS
ID : R42 HL122038
Pays : United States
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