Association of bone mineral density and fat fraction with magnetic susceptibility in inflamed trabecular bone.
Adipose Tissue
/ diagnostic imaging
Adolescent
Adult
Bone Density
Bone Marrow
/ diagnostic imaging
Cancellous Bone
/ diagnostic imaging
Child
Edema
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Magnetics
Phantoms, Imaging
Protons
Reproducibility of Results
Spondylarthritis
/ diagnostic imaging
Young Adult
QSM
bone marrow
bone mineral density
inflammation
magnetic susceptibility
proton density fat fraction
spondyloarthritis
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
28
08
2018
revised:
19
11
2018
accepted:
20
11
2018
pubmed:
8
1
2019
medline:
25
3
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
To evaluate the relationship between bone mineral density (BMD) and magnetic susceptibility, and between proton density fat fraction and susceptibility, in inflamed trabecular bone. Two different phantoms modeling the fat fraction (FF) and BMD values of healthy bone marrow and disease states were scanned using a multiecho gradient echo acquisition at 3T. After correction for fat-water chemical shift, susceptibility mapping was performed, and susceptibility measurements were compared with BMD and FF values using linear regression. Patients with spondyloarthritis were scanned using the same protocol, and susceptibility values were calculated in areas of inflamed bone (edema) and fat metaplasia, both before and after accounting for the contribution of fat to the total susceptibility. Susceptibility values in the phantoms were accurately described by a 2D linear function, with a negative correlation between BMD and susceptibility and a positive correlation between FF and susceptibility (adjusted R BMD and proton density fat fraction both influence the total susceptibility of bone marrow and failure to account for the fat contribution could lead to errors in BMD quantification. We propose a method for removing the fat contribution from the total susceptibility, based on the observed linear relationship between susceptibility and FF. In inflamed bone, the overall increase in susceptibility in areas of fat metaplasia is at least partly due to increased fat content.
Identifiants
pubmed: 30615213
doi: 10.1002/mrm.27634
pmc: PMC6492090
doi:
Substances chimiques
Protons
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3094-3107Subventions
Organisme : EPSRC
Pays : International
Organisme : Engineering and Physical Sciences Research Council
ID : EP/LO16478/1
Pays : International
Organisme : Biomedical Research Centre
Pays : International
Organisme : Arthritis Research UK
ID : 21369
Pays : United Kingdom
Organisme : UCLH Biomedical Research Centre
Pays : International
Organisme : UCL Centre for Doctoral Training in Medical Imaging
ID : (EP/L016478/1)
Pays : International
Organisme : Versus Arthritis
ID : 21369
Pays : United Kingdom
Informations de copyright
© 2019 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
Références
Ann Rheum Dis. 2009 Jun;68 Suppl 2:ii1-44
pubmed: 19433414
Eur J Radiol. 1998 Jan;26(2):177-82
pubmed: 9518226
Magn Reson Med. 2010 Jan;63(1):194-206
pubmed: 19953507
IEEE Trans Med Imaging. 2015 Feb;34(2):531-40
pubmed: 25312917
Magn Reson Med. 2015 Jan;73(1):82-101
pubmed: 25044035
Ann Rheum Dis. 2009 Aug;68(8):1334-9
pubmed: 18678577
Magn Reson Med. 2018 Jan;79(1):121-128
pubmed: 28261863
NMR Biomed. 2011 Nov;24(9):1129-36
pubmed: 21387445
J Lipid Res. 2008 Sep;49(9):2055-62
pubmed: 18509197
Magn Reson Med. 2012 Aug;68(2):378-88
pubmed: 22693111
NMR Biomed. 2017 Apr;30(4):
pubmed: 27906525
J Magn Reson Imaging. 2015 Jul;42(1):23-41
pubmed: 25270052
AJR Am J Roentgenol. 1997 Nov;169(5):1439-47
pubmed: 9353477
Comput Methods Programs Biomed. 2010 Jun;98(3):278-84
pubmed: 19818524
Magn Reson Med. 2018 Mar;79(3):1661-1673
pubmed: 28762243
Magn Reson Med. 2010 Jun;63(6):1659-68
pubmed: 20512869
Ann Rheum Dis. 2008 Sep;67(9):1276-81
pubmed: 18006539
Lancet. 2007 Apr 21;369(9570):1379-1390
pubmed: 17448825
Magn Reson Med. 2019 May;81(5):3094-3107
pubmed: 30615213
Magn Reson Med. 2017 Jul;78(1):264-270
pubmed: 27509836
Expert Opin Emerg Drugs. 2018 Mar;23(1):83-96
pubmed: 29475394
Magn Reson Med. 2017 Jul;78(1):204-214
pubmed: 27529579
Magn Reson Med. 2015 Jun;73(6):2100-10
pubmed: 24947227
Clin Neuroradiol. 2015 Oct;25 Suppl 2:225-30
pubmed: 26198880
J Rheumatol. 2015 Jan;42(1):79-86
pubmed: 25320219
Phys Med Biol. 2017 Jun 7;62(11):4237-4253
pubmed: 28291745
Radiology. 2015 May;275(2):570-8
pubmed: 25575118
Arthritis Rheumatol. 2014 Nov;66(11):2958-67
pubmed: 25047851
IEEE Trans Med Imaging. 2010 Feb;29(2):273-81
pubmed: 19502123
Magn Reson Med. 2013 Jun;69(6):1582-94
pubmed: 22791625
Magn Reson Med. 2009 Dec;62(6):1510-22
pubmed: 19859937
Eur Radiol. 2015 Oct;25(10):2869-79
pubmed: 25903702
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
J Bone Miner Res. 1997 Jan;12(1):111-8
pubmed: 9240733
Magn Reson Med. 2018 Feb;79(2):1031-1042
pubmed: 28589660
J Magn Reson Imaging. 2018 Oct;48(4):1069-1079
pubmed: 29566449
Arthritis Rheum. 2005 Oct 15;53(5):703-9
pubmed: 16208659