Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?
Campylobacter
Colo-rectal cancer
Crohn’s disease
Dysbiosis
Enteropathogen
Giardia
Inflammatory bowel disease
Iron
Metabolome
Microbiome
Microbiota biofilm
Mucus
Pathobionts
Post-infectious IBS
Journal
Journal of biomedical science
ISSN: 1423-0127
Titre abrégé: J Biomed Sci
Pays: England
ID NLM: 9421567
Informations de publication
Date de publication:
03 Jan 2019
03 Jan 2019
Historique:
received:
29
08
2018
accepted:
21
12
2018
entrez:
4
1
2019
pubmed:
4
1
2019
medline:
2
2
2019
Statut:
epublish
Résumé
Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these microbiota communities, and how in turn their disruptions may cause disease. Beyond alterations of relative microbial abundance and diversity, the aim of the review is to focus on the disruptions of the microbiota biofilm structure and function, the dispersion of commensal bacteria, and the mechanisms whereby these dispersed commensals may become pathobionts. Recent findings have linked iron acquisition to the expression of virulence factors in gut commensals that have become pathobionts. Causal studies are emerging, and mechanisms common to enteropathogen-induced disruptions, as well as those reported for Inflammatory Bowel Disease and colo-rectal cancer are used as examples to illustrate the great translational potential of such research. These new observations shed new light on our attempts to develop new therapies that are able to protect and restore gut microbiota homeostasis in the many disease conditions that have been linked to microbiota dysbiosis.
Identifiants
pubmed: 30602371
doi: 10.1186/s12929-018-0495-4
pii: 10.1186/s12929-018-0495-4
pmc: PMC6317250
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 183-681-2011, 413888-2012
Organisme : Canadian Institutes of Health Research
ID : 12033
Pays : Canada
Organisme : Crohn's and Colitis Canada
ID : 20142017
Organisme : AgreenSkillsPlus
ID : PCOFUND-GA-2013-609398
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