Comparison between men and women of volume regulating hormones and aquaporin-2 excretion following graded central hypovolemia.
Adult
Aquaporin 2
/ metabolism
Blood Pressure
/ physiology
Cardiac Output
/ physiology
Female
Heart Rate
/ physiology
Humans
Hypovolemia
/ etiology
Lower Body Negative Pressure
/ methods
Male
Neurophysins
/ metabolism
Protein Precursors
/ metabolism
Sex Factors
Vascular Resistance
/ physiology
Vasopressins
/ metabolism
Young Adult
Adrenomedullin
Aquaporins
Copeptin
Lower body negative pressure
Orthostatic loading
Vasopressin
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
23
08
2018
accepted:
07
12
2018
pubmed:
20
12
2018
medline:
14
6
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
Central hypovolemia induced by orthostatic loading causes reno-vascular changes that can lead to orthostatic intolerance. In this study, we investigated volume regulating hormonal responses and reno-vascular changes in male and female subjects as they underwent central hypovolemia, induced by graded lower body negative pressure (LBNP). Aquaporin-2 (AQP2) excretion was measured as a biomarker for the renal system response to vasopressin. 37 young healthy subjects (n = 19 males; n = 18 females) were subjected to graded LBNP until - 40 mmHg LBNP. Under resting conditions, males had significantly higher copeptin (a stable peptide derived from vasopressin) levels compared with females. Adrenocorticotropin (ACTH), adrenomedullin (ADM), vasopressin (AVP) and brain natriuretic peptide (BNP) were not affected by our experimental protocol. Nevertheless, an analysis of ADM and BNP with the data normalized as percentages of the baseline value data showed an increase from baseline to 10 min after recovery in the males in ADM and in the females in BNP. Analysis of BNP and ADM raises the possibility of a preferential adaptive vascular response to central hypovolemia in males as shown by the normalized increase in ADM, whereas females showed a preferential renal response as shown by the normalized increase in BNP. Furthermore, our results suggest that there might be a difference between men and women in the copeptin response to alterations in orthostatic loading, simulated either using LBNP or during posture changes.
Identifiants
pubmed: 30564880
doi: 10.1007/s00421-018-4053-2
pii: 10.1007/s00421-018-4053-2
doi:
Substances chimiques
AVP protein, human
0
Aquaporin 2
0
Neurophysins
0
Protein Precursors
0
Vasopressins
11000-17-2
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
633-643Subventions
Organisme : Agenzia Spaziale Italiana
ID : 2013-091-R.0
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