Serotonin 3 receptor signaling regulates 5-fluorouracil-mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells.
Animals
Antimetabolites
/ pharmacology
Apoptosis
/ drug effects
Bone Marrow Cells
/ cytology
Enterochromaffin Cells
/ drug effects
Fluorouracil
/ pharmacology
Green Fluorescent Proteins
/ genetics
Intestine, Small
/ cytology
Mice
Mice, Inbred C57BL
Mice, Knockout
Serine Endopeptidases
/ genetics
Serotonin
/ metabolism
Signal Transduction
Tumor Necrosis Factor-alpha
/ biosynthesis
anti-apoptosis
anti-inflammatory
intestinal epithelial cells
intestinal organoids
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
13
9
2018
medline:
1
10
2019
entrez:
13
9
2018
Statut:
ppublish
Résumé
Antagonists of the 5-hydroxytryptamine (serotonin) 3 receptor (5-HT
Identifiants
pubmed: 30207796
doi: 10.1096/fj.201701200RR
doi:
Substances chimiques
Antimetabolites
0
Tumor Necrosis Factor-alpha
0
enhanced green fluorescent protein
0
Green Fluorescent Proteins
147336-22-9
Serotonin
333DO1RDJY
PRSP protein, mouse
EC 3.4.21.-
Serine Endopeptidases
EC 3.4.21.-
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM