Muscle Wasting Diseases: Novel Targets and Treatments.
atrophy
exon skipping
gene therapy
muscle wasting
muscular dystrophy
proteostasis
Journal
Annual review of pharmacology and toxicology
ISSN: 1545-4304
Titre abrégé: Annu Rev Pharmacol Toxicol
Pays: United States
ID NLM: 7607088
Informations de publication
Date de publication:
06 01 2019
06 01 2019
Historique:
pubmed:
28
8
2018
medline:
9
7
2020
entrez:
28
8
2018
Statut:
ppublish
Résumé
Adequate skeletal muscle plasticity is an essential element for our well-being, and compromised muscle function can drastically affect quality of life, morbidity, and mortality. Surprisingly, however, skeletal muscle remains one of the most under-medicated organs. Interventions in muscle diseases are scarce, not only in neuromuscular dystrophies, but also in highly prevalent secondary wasting pathologies such as sarcopenia and cachexia. Even in other diseases that exhibit a well-established risk correlation of muscle dysfunction due to a sedentary lifestyle, such as type 2 diabetes or cardiovascular pathologies, current treatments are mostly targeted on non-muscle tissues. In recent years, a renewed focus on skeletal muscle has led to the discovery of various novel drug targets and the design of new pharmacological approaches. This review provides an overview of the current knowledge of the key mechanisms involved in muscle wasting conditions and novel pharmacological avenues that could ameliorate muscle diseases.
Identifiants
pubmed: 30148697
doi: 10.1146/annurev-pharmtox-010818-021041
pmc: PMC6701981
mid: EMS84021
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-339Subventions
Organisme : Swiss National Science Foundation
ID : 156654
Pays : Switzerland
Organisme : European Research Council
ID : 616830
Pays : International
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