Animal models of cholangiocarcinoma.
Orthotopic
Transduction
Transgenic
Xenotransplantation
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
20
02
2018
revised:
23
03
2018
accepted:
29
03
2018
pubmed:
9
4
2018
medline:
28
11
2019
entrez:
9
4
2018
Statut:
ppublish
Résumé
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. In an effort to address this challenge, preclinical in vivo studies have become paramount in understanding CCA carcinogenesis, progression, and therapy. Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue. Each type has distinct advantages as well as shortcomings. In the ideal animal model of CCA, the tumor arises from the biliary tract in an immunocompetent host with a species-matched tumor microenvironment. Such a model would also be time-efficient, recapitulate the genetic and histopathological features of human CCA, and predict therapeutic response in humans. Recently developed biliary tract transduction and orthotopic syngeneic transplant mouse models encompass several of these elements. Herein, we review the different animal models of CCA, their advantages and deficiencies, as well as features which mimic human CCA.
Identifiants
pubmed: 29627364
pii: S0925-4439(18)30124-8
doi: 10.1016/j.bbadis.2018.03.026
pmc: PMC6177316
mid: NIHMS959060
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
982-992Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK059427
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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