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Acides aminés, peptides et protéines
Protéines
Hémoprotéines
Cytochromes
Cytochrome P-450 enzyme system
Cytochrome P-450 enzyme system : Questions médicales fréquentes
Diagnostic
5
Cytochrome P-450
Tests de laboratoire
Polymorphisme génétique
Cytochrome P-450
Réactions indésirables aux médicaments
Cytochrome P-450
Médicaments
Cytochrome P-450
Biomarqueurs
Cytochrome P-450
Symptômes
5
Échecs thérapeutiques
Cytochrome P-450
Effets secondaires
Cytochrome P-450
Métabolisme des médicaments
Cytochrome P-450
Intoxication médicamenteuse
Cytochrome P-450
Grossesse
Cytochrome P-450
Prévention
5
Interactions médicamenteuses
Cytochrome P-450
Conseils aux patients
Cytochrome P-450
Effets indésirables
Cytochrome P-450
Tests génétiques
Cytochrome P-450
Éducation des patients
Cytochrome P-450
Traitements
5
Ajustement de dose
Cytochrome P-450
Inhibiteurs enzymatiques
Cytochrome P-450
Gestion des médicaments
Cytochrome P-450
Traitement symptomatique
Cytochrome P-450
Surveillance thérapeutique
Cytochrome P-450
Complications
5
Réactions allergiques
Cytochrome P-450
Maladies hépatiques
Cytochrome P-450
Plantes médicinales
Cytochrome P-450
Infections
Cytochrome P-450
Facteurs de risque
5
Facteurs génétiques
Cytochrome P-450
Habitudes alimentaires
Cytochrome P-450
Tabagisme
Cytochrome P-450
Anticonvulsivants
Cytochrome P-450
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"name": "Comment éduquer les patients sur les médicaments ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients doivent être informés des risques associés aux médicaments et de leur métabolisme."
}
},
{
"@type": "Question",
"name": "Comment traiter une suractivité du cytochrome P-450 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'ajustement des doses médicamenteuses et l'évitement de certains médicaments peuvent être nécessaires."
}
},
{
"@type": "Question",
"name": "Quels médicaments inhibent le cytochrome P-450 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme le kétoconazole peuvent inhiber certaines enzymes P-450."
}
},
{
"@type": "Question",
"name": "Comment gérer une sous-activité ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des doses plus faibles de médicaments peuvent être nécessaires pour éviter l'accumulation."
}
},
{
"@type": "Question",
"name": "Quels traitements pour les effets secondaires ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements symptomatiques peuvent être administrés pour gérer les effets indésirables."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests réguliers des niveaux de médicaments dans le sang peuvent aider à ajuster le traitement."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des réactions allergiques ou des échecs thérapeutiques peuvent se produire."
}
},
{
"@type": "Question",
"name": "Comment les maladies hépatiques affectent-elles le cytochrome P-450 ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies hépatiques peuvent réduire l'activité des enzymes P-450, affectant le métabolisme des médicaments."
}
},
{
"@type": "Question",
"name": "Quels risques liés à l'alcool ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La consommation excessive d'alcool peut induire certaines enzymes P-450, modifiant le métabolisme."
}
},
{
"@type": "Question",
"name": "Quelles interactions avec les plantes médicinales ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes peuvent inhiber ou induire les enzymes P-450, entraînant des interactions médicamenteuses."
}
},
{
"@type": "Question",
"name": "Quels effets des infections sur le cytochrome P-450 ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections peuvent altérer l'activité des enzymes P-450, affectant le métabolisme des médicaments."
}
},
{
"@type": "Question",
"name": "Quels facteurs génétiques influencent le cytochrome P-450 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des variations génétiques peuvent affecter l'activité des enzymes P-450, modifiant le métabolisme."
}
},
{
"@type": "Question",
"name": "Comment l'âge affecte-t-il le cytochrome P-450 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge peut influencer l'activité enzymatique, avec des variations notables chez les personnes âgées."
}
},
{
"@type": "Question",
"name": "Quels effets des habitudes alimentaires ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en graisses ou en certains nutriments peut influencer l'activité P-450."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme impacte-t-il le cytochrome P-450 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme peut induire certaines enzymes P-450, augmentant le métabolisme de certains médicaments."
}
},
{
"@type": "Question",
"name": "Quels médicaments augmentent le risque d'interactions ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les anticonvulsivants peuvent induire des enzymes P-450, augmentant les interactions."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 18/01/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
Publications dans "Cytochrome P-450 enzyme system" :
3 publications dans cette catégorie
Affiliations :
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia (S.J.S., J.J.D.V., E.M.J.G.); and DMPK, Early Cardiovascular, Renal and Metabolism (U.J.) and Discovery Sciences (S.A.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary. Electronic address: poor.miklos@pte.hu.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 Shandong, China.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, Robert-Koch-Straße 4, 35037 Marburg, Germany.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China (D.-Z.T., F.Z., R.-J.H., Y.W., X.-H.Z., G.-B.G.); Heilongjiang Key Laboratory of Tissue Damage and Repair, Mudanjiang Medical University, Heilongjiang, China (X.M.); Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China (X.M., J.Z.); Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China (J.-J.W.); and State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China (J.Z.) zhengneu@yahoo.com geguangbo@dicp.ac.cn.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Center for Natural Products Research, Chinese Academy of Sciences , Chengdu Institute of Biology , 9 Section 4, Renmin Road South , Chengdu 610041 , China.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 30072, China. Electronic address: matthias@tju.edu.cn.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Publications dans "Cytochrome P-450 enzyme system" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia.
Publications dans "Cytochrome P-450 enzyme system" :
1 publication dans cette catégorie
Affiliations :
Western University of Health Sciences, School of Pharmacy, Pomona, CA, United States.
Publications dans "Cytochrome P-450 enzyme system" :
1 publication dans cette catégorie
Affiliations :
Western University of Health Sciences, School of Pharmacy, Pomona, CA, United States.
Publications dans "Cytochrome P-450 enzyme system" :
1 publication dans cette catégorie
Affiliations :
Western University of Health Sciences, School of Pharmacy, Pomona, CA, United States.
Publications dans "Cytochrome P-450 enzyme system" :
1 publication dans cette catégorie
Affiliations :
Western University of Health Sciences, School of Pharmacy, Pomona, CA, United States.
Publications dans "Cytochrome P-450 enzyme system" :
1 publication dans cette catégorie
Affiliations :
University of California, Irvine, School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, United States.
Publications dans "Cytochrome P-450 enzyme system" :
Bariatric surgeries are becoming more prevalent as obesity rates continue to rise. Being that it is an effective weight-loss procedure, it can induce significant anatomical, physiological, and metabol...
Consumption of herbs, food used as medicine and dietary supplements (HFDSs) is common in cancer patients. Herbs and food-drug interactions (HFDIs) can lead to serious adverse effects and can be preven...
We conducted a prospective, non-interventional study (NCT04128865) to assess whether self-assessment of patients could detect HFDI classified as 'probable' (i.e. level 1, 2 or 3 of the scale) in a pop...
Between 29 March 2018 and 22 June 2018, 143 patients completed the survey. Ninety-five patients (66%) reported at least one current systemic cancer treatment and were included in the analyses. Seventy...
Self-assessment of HFDS interaction with cancer treatment with an application is feasible and should be considered in daily routine. Prospective interventional studies should be conducted to better as...
Cytochrome P450 enzymes (CYPs) are involved in metabolic steps that provide structural diversity during the biosynthesis of carotenoids and their oxidative cleavage products called apocarotenoids. Rec...
Cytochrome P450 enzymes are monooxygenases widely diffused in nature ranging from viruses to man. They can catalyze a very wide range of reactions, including the ketonization of C-H bonds, N/O/S-dealk...
NADPH-cytochrome P450 reductase delivers electrons required by heme oxygenase, squalene monooxygenase, fatty acid desaturase, and 48 human cytochrome P450 enzymes. While conformational changes support...
Cytochrome P450 monooxygenases (CYPs/P450s) and their redox partners, ferredoxins, are ubiquitous in organisms. P450s have been studied in biology for over six decades owing to their distinct catalyti...
Atypical kinetics are observed in metabolic reactions catalyzed by cytochrome P450 enzymes (P450). Yet, this phenomenon is regarded as experimental artifacts in some instances despite increasing evide...
Cadmium (Cd), known as a vital contaminant in the environment, penetrates the blood-brain barrier and accumulates in the cerebrum. Acute toxicosis of Cd, which leads to lethal cerebral edema, intracel...
This work was executed to research the protective effects of RES against Cd-induced toxicity in chicken cerebrum. Markedly, these lesions were increased in the Cd group, which also exhibited a thinner...
RES initiated NXRs (especially for aromatic receptor and pregnancy alkane X receptor), decreasing the expression of CYP450 genes, changing the content of CYP450, maintaining CYP450 enzyme normal activ...
The steroid binding CYP142 cytochrome P450 enzymes of...
Dendrobine is the major active ingredient of...